摘要
目的探讨原发性乳腺淋巴瘤（PPC）的临床病理特征、治疗经过及预后相关因素。方法分析11例PPC患者的不同病因的原发性腹膜癌患者生存时间进行比较,分析其临床发病特点、治疗经过及疗效、预后随访结果。结果 11例患者以腹胀、腹水、纳差为主要首发症状,均为女性,中位年龄56岁（46-62岁）,病理为不同分化程度的浆液性乳头状囊腺癌9例,粘液性乳头状腺癌2例。8例施行肿瘤细胞减灭术,3例仅行腹腔镜探查及活检。术中均给予卡铂200mg腹腔保留,术后给予铂类为主的方案化疗至少6周期。1例放弃治疗失访。随访〈2年4例,均无瘤生存。大于2年6例,死亡1例,其2年生存率60%,3年生存率50%。结论 PPC原发于腹膜间皮,是一种起病隐匿,发病率较低,临床症状和体征无特异性,误诊率高的疾病,应重视其术前诊断及鉴别诊断,以减少误诊率。采用肿瘤细胞减灭术和以铂类为主方案的化疗可显著改善预后,提高患者的生存期。化疗方案是预后的影响因素。
Objective To explore the clinicopathologic features,optimal treatment and prognostic factors of primary peritoneal carcinoma（PPC）.Methods The clinical records of 11 PPC patientswere retrospectively reviewed.Results The most common symptoms included abdominal distention,increasing abdominal girth（asciters）,anorexia and loss of weigh.The patients were all female with an average age of 56 years old.Pathological findings showed that 9 cases were serous papillary cystadenocarcinoma and 2 cases were mucous papillary adenocarcinoma. 8 patients were treated with cytoreductive operation,3 with diagnostic laparoscopy and biopsy.All patients were treated with abdominal keeping of 200 mg of platinum during operation and followed by systemic chemotherapy of platin-based regimen no less than 6 cycles.Only 1 case died of cancer.2-and 3-year survival rates were 60.0% and 50%,respectively.Conclusion Great attention should be paid to the diagnosis of primary carcinoma of peritoneum especially to the patients with abdominal distention and ascites.The long time survival rate of patients may be improved by active cytoreductive surgery followed by chemotherapy of platin-based regimen.Chemotherapy regimens are the essential factors of the prognosis.
出处
《西部医学》
2011年第9期1653-1655,共3页
Medical Journal of West China
关键词
腹膜癌
原发性
预后
Peritoneal neoplasm
Primary
Prognosis
