摘要
目的观察奎硫平与丙戊酸钠缓释片治疗双相障碍躁狂发作的疗效和安全性。方法利用随机对照方法,将103例双相情感障碍躁狂发作患者分为奎硫平组51例和丙戊酸钠缓释片组52例。观察疗程均为6周,于治疗前以及治疗2,4,6周末采用Young躁狂评定量表、阳性和阴性症状量表(PANSS)评定临床疗效。结果 Young躁狂评定量表减分值比较显示,奎硫平组有效率为70.59%,丙戊酸钠组有效率为71.15%,疗效相近(P>0.05),但奎硫平组治疗2周末Young躁狂评定量表减分较丙戊酸钠缓释片组下降更快(P<0.05);两组不良反应发生率无显著差异性(P>0.05)。丙戊酸钠组的脱落率大于奎硫平组。结论奎硫平治疗双相情感障碍躁狂发作与丙戊酸钠缓释片治疗效果相同,安全性高,起效更快,更适合躁狂急性期的治疗。
Objective To investigate the effectiveness and safety of quetiapine and Sodium Valproate Sustained Release Tablets（SVSRT） in treating bipolar disorder manic episode.Methods We enrolled 103 patients with bipolar disorder manic episode and randomly allocated them into two groups：quetiapine group（51 cases） and Sodium Valproate Sustained Release Tablets（SVSRT） group（52 cases）.During 6-week follow-up period,the therapeutic efficacy was evaluated using Young Mania Rating Scale（YMRC） and Positive and Negative Syndrome Scale（PANSS） before treatment and at the end of 2,4,6 weeks after initiation of treatment.Results Comparing the decreased scores of YMRC showed that the effective rate was 70.59%in quetiapine group and 71.15%in VSRT group,revealing the effect of quetiapine and SVSRT was similar in treating acute mania.But the decreased scores at the end of 2-week treatment in quetiapine group were declined faster than those in SVSRT group with statistical difference（P 0.05）,indicating faster action and rapid onset of quetiapine in controlling symptom of mania.The incidence rate of adverse reactions in two groups had no significant difference（P 0.05）.The withdrawal rate of patients in VSRT group was higher than that in quetiapine group.Conclusion Single quetiapine is as effective as SVSRT in treating bipolar disorder manic episode with faster onset of action and considerable safety,which is suitable for treating acute phase of mania episode.
出处
《中国药业》
CAS
2011年第19期72-73,共2页
China Pharmaceuticals
关键词
双相障碍
躁狂发作
奎硫平
丙戊酸钠缓释片
bipolar disorder
mania episode
quetiapine
Sodium Valproate Sustained Release Tablets
