摘要
CD4^＋CD25^＋Treg细胞的主要作用表现为免疫无能性和免疫抑制性，是外周免疫耐受形成机制的主要组成部分。其主要作用机制为分泌抑制性细胞因子（IL-10和TGF-β3）、表达细胞表面分子（CTLA-4、GITR等）及Foxp3等。支气管哮喘患者外周血CD4^＋CD25^＋Treg功能及数量存在异常，这可能是支气管哮喘发病机制之一。糖皮质激素可以通过影响CD4^＋CD25^＋Treg的状态起到抑制支气管哮喘气道炎症的作用。
The main function of CD4^＋ CD25^＋ Treg cells are immunological anergy and inhibition, which is essential to the maintenance of immunological tolerance in the host. CD4^＋ CD25^＋ Treg cells produce inhibitory cytokines （TGF-β and IL-10）, express membrane molecules （CTLA-4,GITR, etc） and Foxp3. There are abnormal in function and quantity of CD4^＋ CD25^＋ Treg cells of peripheral blood from asthmatic patients, which maybe one of the pathogenesis of asthma. Glucoeorticoids can inhibit the airway inflamation of asthma by impacting CD4^＋ CD25^＋Treg cells.
出处
《国际呼吸杂志》
2011年第19期1485-1487,共3页
International Journal of Respiration
