摘要
目的:观察周剂量多西他赛+卡培他滨与奥沙利铂+卡培他滨(XELOX方案)两种化疗方案治疗晚期胃癌的近期疗效及不良反应。方法:60例晚期胃癌患者随机分成两组,A组32例(采用周剂量多西他赛联合卡培他滨方案化疗),B组28例(采用XELOX方案化疗),两组均完成2个周期以上化疗。结果:入组60例均可评价疗效,A组有效率为53.13%(17/32),TTP为6.7个月,MST为11.8个月。B组有效率为50.00%(14/28),TTP为5.6个月,MST为11个月。两组近期有效率差异无统计学意义(P>0.05)。不良反应比较,A组3～4白细胞减少率、脱发发生率明显高于B组(P<0.05);B组周围神经炎发生率明显高于A组(P<0.05)。结论:两种化疗方案治疗晚期胃癌均有较好的近期疗效,可根据患者实际情况进行选择,XELOX方案的不良反应更易耐受,且对体质差、骨髓耐受差、老年患者更适合。
Objective： To compare the effect of docetaxel and capecitabine and effect of XELOX on advanced gastric cancer. Methods： A total of 60 cases with advanced gastric cancer were randomly divided into two groups. Thirty two patients in group A were treated by docetaxel and capecitabine at weekly dosage, while 28 patients in group B were treated by XELOX. Two group were treated for longer than two course. Results： The efficacy was 53.13% （17/32）, with TTP as 6.7 months, and MST as 11.8 months in group A; while the efficacy was 50.00%, with TTP as 5.6 months, MST 11 months in group B. There was no significant difference in short term efficacy（P〉0.05）. The incidences of leucopenia and alopecia were significantly higher in group A（P〈0.05）, while the incidence of peripheral neuritis was significantly higher in group B（P^0.05）. Oonclusions, Two treatments have satisfactory effect in short term, and can be selected dependently on patientsr situation. The side effect of XELOX is more tolerable, and can be used to treat elder patients with poor physical status and poor tolerance of marrow.
出处
《海南医学院学报》
CAS
2011年第11期1497-1499,1503,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110412)~~
关键词
晚期胃癌
多西他赛
卡培他滨
奥沙利铂
联合化疗
Advanced gastric cancer
Docetaxel
Capecitabine
Oxaliplatin
Combined chemo-therapy
