摘要
主要对中药经鼻腔给药研究进行文献整理和分析。研究表明,中药经鼻腔给药可以在鼻腔起局部治疗作用,或经鼻吸收后向脑内递药发挥中枢治疗作用,还可以起到治疗全身性疾病的作用。综述了近年来中药经鼻腔给药的实验研究及临床运用,主要包括鼻用制剂国内现状、中药经鼻腔给药基础实验研究(给药途径的选择、剂型的选择、辅料的选择、体外释药评价、药代动力学研究、药效学研究、脑靶向性、安全评价)、中药鼻用制剂的临床观察实例研究,并对其进行了展望,以期为中药经鼻腔给药临床疾病治疗应用和中药鼻用制剂新药开发提供参考。
The field of intranasal administration of traditional Chinese medicine is illustrated in this review article.Intranasal administration of traditional Chinese medicine has a local effect on nasal cavity,or delivered from nose to brain to show a centralnervons treatment as well as works in curing systemic diseases.This paper makes an overview of expenrimental study（the route of administration,dosage form selection,the choice of excipients,evaluation of drug release in vitro,pharmacokinetics,pharmacodynamics,brain targeting,safety evaluation） and clinical applications on intranasal administration of Chinese Medicine in recent years and has a bright future,expecting to provide reference for new drug of intranasal preparation of traditional Chinese medicine.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第20期288-293,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中医药行业科研专项项目(200708006)
"十一五"重大新药创制项目(2009ZX09310-005
2009ZX09103-393)
关键词
经鼻给药
鼻用制剂
吸收促进剂
靶向性
intranasal administration
nasal preparation
absorption enhancer
targeting
