摘要
目的探讨血清白细胞介素-18(IL-18)和基质金属蛋白酶-9(MMP-9)的检测在急性冠脉综合征中的应用价值。方法采用酶联免疫吸附法(ELISA法)测定150例患者的血清IL-18、MMP-9水平。结果血清IL-18、MMP-9水平在急性冠状动脉综合征患者中明显增高,与对照组和稳定型心绞痛组间差异有统计学意义(P<0.05);双支和三支血管病变患者血清IL-18、MMP-9水平高于正常对照组,组间比较差异有统计学意义(P<0.05)。结论 ACS患者血清IL-18和MMP-9水平增高,有望作为ACS斑块稳定性的预测因子。检测血清IL-18、MMP-9对急性冠脉综合征患者有重要的临床价值。
Objective To investigate the application of serum levels of interleukin-18（IL-18） and matrix metalloproteinase-9（MMP-9） detection in acute coronary symptoms.Methods The enzyme-linked immunosorbent assay（ELISA） determination of 150 patients with serum IL-18,MMP-9 levels.Results Serum IL-18,MMP-9 levels in 9 patients with acute coronary syndrome was significantly higher in the control group and stable angina pectoris difference between the two groups was statistically significant（P〈0.05）;Double support and three vascular disease in patients with serum IL-18,MMP-9 levels higher than those of the control group,the difference between groups was statistically significant（P〈0.05）.Conclusions ACS serum IL-18 and MMP-9 levels increased plaque stability is expected as a predictor of ACS.Serum IL-18,MMP-9 in patients with acute coronary syndrome has important clinical value.
出处
《医药论坛杂志》
2011年第17期19-20,共2页
Journal of Medical Forum
