摘要
目的探讨胰腺实性-假乳头状瘤(solid-pseudopapillary tumor,SPPT)的临床病理特征及免疫表型。方法对16例SPPT的临床表现、病理学特征、免疫组化特点进行总结分析。结果 16例患者有14例为女性,且术后无复发。肿瘤主要发生在胰头和胰尾,有包膜,囊实性相间,并且常见有出血。瘤细胞围绕纤维血管排列形成假乳头状或假花环状结构是特征性组织学改变。免疫组织化学结果显示,所有SPPT的E-cadherin表达均为阴性,并且其β-catenin染色均呈现胞核及胞质阳性,而正常胰腺组织E-cadherin及β-catenin均有表达,呈现膜阳性信号。16例中14例SPPT中cyclinD1的核染色阳性率大多在70%-75%,与正常胰腺组织(0/16)相比明显升高(87.5%vs 0,χ2=24.89,P<0.05)。结论 SPPT是低度恶性肿瘤,极少发生复发,多发生在青春期女孩和年轻女性。免疫组化E-cadherin、β-catenin及CyclinD1的检测对SPPT的诊断具有提示意义。
Objective To investigate the clinicopathological features and immunological phenotype of solid-pseudopapillary tumor of the pancreas（SPPT）. Methods The clinical features,pathological and immunohistochemical changes of 16 cases of solid-pseudopapillary tumor of the pancreas were analyzed. Results Of 16 cases,14 were female.No postoperative recurrence occurred.Tumors were found in head and tail of the pancreas,encapsulated,cystic or solid,and bleeding.Pseudopapillary or artificial flowers ring structure was the specific histological changes.Immunohistochemical results showed that all patients were negative for E-cadherin,but positive for β-catenin in nucleus and cytoplasm.Both E-cadherin and β-catenin were expressed in membrane of normal pancreas.The positive rate of cyclinD1 was 70%-75% in 14 cases of SPPT,significantly higher than that of normal pancreatic tissues（87.5% vs 0,χ2=24.89,P0.05）. Conclusion SPPT is a low-grade malignant tumor,rarely relapses,and mainly occurs in adolescent girls and young women.E-cadherin,β-catenin and cyclin D may be important markers for the diagnosis of SPPT.
出处
《山西医科大学学报》
CAS
2011年第10期814-817,858,共5页
Journal of Shanxi Medical University
关键词
胰腺实性-假乳头状瘤
病理学
免疫组化
solid-pseudopapillary tumor of the pancreas
pathology
immunohistochemistry
