摘要
目的探讨颈动脉颅外段粥样硬化与不同年龄段患者脑梗死的关系。方法选取本院2008年1月至2010年1月诊治的130例脑梗死患者,根据患者年龄分布分为3组,即40～<56岁为A组,56～<66岁为B组,≥66岁为C组,分别测定并比较3组患者总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、纤维蛋白原(FIB)水平,并检测颈动脉粥样硬化程度和斑块性质。结果 B组和C组患者TG、FIB显著高于A组,HDL显著低于A组,B组和C组患者颈动脉粥样硬化程度和不稳定斑块发生率显著高于A组,差异均有统计学意义(P<0.05),B组与C组组间比较差异无统计学意义。结论血脂及FIB与颈动脉颅外段粥样硬化的发生、发展及斑块的稳定性密切相关,中老年患者较其他年龄段患者而言,颈动脉颅外段粥样硬化程度更为严重且以不稳定性斑块居多。因此,对于颈动脉颅外段粥样硬化患者,可通过测定血脂及FIB水平对疾病进行早期防治及预测预后。
Objective To study the correlation of extracranial carotid artery atherosclerosis and cerebral infarction in different age. Methods 130 cerebral infarction patients were selected from January 2008 to January. According to the patient age they were divided into three groups, 40 and 55 years old for group A, 56-65 for group B, and 66 for group C. Total cholesterol （TC）, tri giycerides （TG）, high density lipoprotein （HDL）, fibrinogen （FIB）, and the detection of carotid atherosclerotic degree and plaques properties of three groups were determined and compared. Results Group B and C groups of patients the triglycerides, fibrinogen, carotid atherosclerosis degree and unstable plaques of group B and C were significantly higher than that of group A, while the high density lipoprotein （HDL） significantly was lower than group A（P〈0.05）. And there was no significant differences between group B and C. Conclusion The fibrinogen is closely related to the blood lipid , dynamic atherosclerotic carotid plaques, and the occurrence, development and the stability of elderly patients. Compared with other age groups concerned, carotid artery atherosclerosis degree is more serious dynamic instability in the majority. Therefore, to patch carotid atherosclerosis patients, can move through measuring blood lipid and fibrinogen level on disease prevention, control and forecast early prognosis certain clinical significance.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第30期3051-3052,3065,共3页
Chongqing medicine
关键词
动脉粥样硬化
脑梗死
纤维蛋白原
atherosclerosis
brain infarction
lipid
fibrinogen
