摘要
建立了动物尿液样品中泼尼松(Prednisone)、泼尼松龙(Prednisolone)、甲基泼尼松龙(Methylprednisone)、地塞米松(Demxamethasone)、倍他米松(Betamethasone)、倍氯米松(Beclometasone)、醋酸氟氢可的松(Fludrocortisone Acetate)、醋酸可的松(Cortisone Acetate)、氢化可的松(Hydrocortisone)等9种糖皮质激素类药物的测定方法,明确规定了适用范围、确定了取样量、酶解、提取净化等方法以及液相色谱条件、串联质谱条件等。该方法具有较好的灵敏度、准确度和精密度。
This paper studied the detection method of nine kinds of glucocorticoid（prednisone,prednisolone,methylprednisone,demxamethasone,betamethasone,beclometasone,fludrocortisone acetate,cortisone acetate and hydrocortisone）in urine using liquid chromatographic-tandem mass spectrometry method,defined the sphere of application,determined the sampling quantity,purification,extraction method,liquid chromatography and tandem mass spectrometry conditions.It showed that this method has good sensitivity,accuracy and precision.
出处
《中国兽药杂志》
2011年第5期26-29,共4页
Chinese Journal of Veterinary Drug
关键词
尿液
糖皮质激素
液相色谱-串联质谱
urine
glucocorticoid
liquid chromatographic-tandem mass spectrometry
