摘要
炎症性肠病(IBD)的病因和发病机制目前尚不清楚。有研究显示IBD患者存在肠道内菌群失调,补充益生菌纠正菌群失调,可使IBD病情缓解。该文针对肠道菌群与IBD发病的相关性,菌群紊乱与肠道免疫功能异常、肠黏膜屏障功能缺陷、肠道通透性增高等的关系,探讨益生菌对IBD的治疗作用。随着人类对肠道黏膜免疫系统及IBD遗传易感性研究的不断完善,益生菌制剂将是一类有广阔前景的治疗IBD的药物。
The etiology and pathogenesis of inflammatory bowel disease（IBD）is unclear.Studies have showed that probiotic supplement can correct dysbacteriosis and alleviate IBD patient＇s condition.This article will explore the role of enterobacteria in development of IBD and the relationships between flora disturbance and abnormalities of intes-tinal immune function,intestinal mucosa function defects and increase of intestinal permeability,Further it will address the therapeutic effect of probiotics in IBD.With the improvement in recognition of intestinal mucosa immune system and genetic susceptibility of IBD,probiotics will become a class of great promising treatment drugs in IBD.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2011年第10期906-909,共4页
Journal of Clinical Pediatrics
关键词
炎症性肠病
肠道菌群
儿童
inflammatory bowel disease
intestinal flora
child
