摘要
目的比较两种全身麻醉快速诱导方法对芬太尼诱发咳嗽反应的影响。方法 210例ASA Ⅰ级或Ⅱ级患者随机均分为实验组(Ⅰ)和对照组(Ⅱ),麻醉诱导方法分别为:组Ⅰ依次静脉注射咪达唑仑0.05mg/kg、异丙酚2mg/kg、罗库溴铵1mg/kg、芬太尼2μg/kg;组Ⅱ依次静脉注射咪达唑仑0.05mg/kg、芬太尼2μg/kg、异丙酚2mg/kg、罗库溴铵1mg/kg。两组病人于诱导后2分钟进行气管插管,观察插管前咳嗽反应的发生率及严重程度,记录诱导前(T_1)、诱导后(T_2)、咳嗽时(T_3)、插管时(T_4)的SPO_2、ABP和HR。结果两组病人一般情况,T_1、T_2、T_3、T_4时间点的SPO_2、ABP和HR差异无统计学意义;组Ⅰ咳嗽的发生率为1.9%,明显低于组Ⅱ的35.2%;组内比较咳嗽时(T_3)的ABP、HR均较T_1、T_2明显升高。结论全身麻醉快速诱导的给药顺序对芬太尼所致咳嗽反应的发生率有明显影响。
Objective To compare the incidence and severity of fentanyl-induced cough following different anesthesia induction methods. Methods Two hundreds and ten patients undergoing general anesthesia, ASA Ⅰ or II, were randomly divided into experimental group （ Ⅰ ） and the control group （ Ⅱ ）, the anesthesia induction methods respectively is： group Ⅰ successively Ⅳ. midazolam 0.05mg/kg, propofol 2mg / kg, rocuronium lmg/kg, fentany12μg/ kg, group Ⅱ successively Ⅳ. midazolam 0. 05mg/kg, fentanyl 2μg/kg, propofol 2mg/kg, rocuronium 1 mg/kg. All patients were intubated at 2 min after injection, The incidence and severity of fentanyl-induced cough before intubation were recorded, SPO2, ABP and HR were observed at time before induction （ T1 ）, after induction （ T2 ）, coughing （T3） , intubation （T4） . Results SPO2, ABP and HR were no significant difference in T1, T2, T3, T4 between two groups of patients; The incidence of fentanyl-induced cough was 1.9% in group Ⅰ ,which significantly lower than the 35.2% in group Ⅱ （P 〈 0.01 ） ; In two groups of patients, ABP and HR at coughing （T3 ） were significantly higher than that at T1, T2 （P 〈0.01 ）. Conclusion Anesthetic injecting sequence during induction affect on fentanyl-induced cough significantly, two kinds of anesthesia induction methods have no significant difference in depressing reaction of intubation.
出处
《中国医刊》
CAS
2011年第11期37-39,共3页
Chinese Journal of Medicine
