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非对数滴定法测定葡萄内酯的解离常数 被引量：4

Nonlogarithmic Titration Method for the Determination of Dissociation Constant of Auraptene
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摘要 目的测定水不溶弱碱性药物葡萄内酯的解离常数(pKb)。方法采用Benet法和Chtten and Harris法。利用葡萄内酯易溶于丙酮的性质,选用不同比例丙酮-水混合物为溶剂进行滴定,然后利用Benet法进行pKb的计算。结果葡萄内酯pKb为9.7527,为弱碱性药物。结论 Benet法和Chtten and Harris法可有效测定难溶于水的弱碱性药物的pKb。 Objective To determine the dissociation constant of auraptene which is an insoluble alkalescent drug.Methods Different acetone-water mixtures were used instead of water to titrate.The pKb was calculated by nonlogarithmic titratl curves（Benet method）.Results The PKb of｜ auraptene was 9.7527.Conclusion The method can be used for the determination of dissociation constant of insoluble alkalescent drugs.
作者 黎艳刚 陈海芳 涂明珠 魏玲 王发英 杨武亮
机构地区 江西中医学院现代中药制剂教育部重点实验室 江西省九江市第一人民医院 浙江省丽水市食品药品检验所
出处 《时珍国医国药》 CAS CSCD 北大核心 2011年第6期1304-1305,共2页 Lishizhen Medicine and Materia Medica Research
基金 国家自然科学基金(No.30660230) 重大新药创制项目(No.2009ZX09103-350)
关键词 葡萄内酯 解离常数 滴定 Auraptene Dissociation constant Titrate
分类号 R969.1 [医药卫生—药理学]
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参考文献9

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二级参考文献6

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共引文献41

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时珍国医国药
2011年 第6期

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