摘要
目的探讨CyclinE在胃癌及淋巴结转移癌组织中的表达意义。方法采用免疫组织化学染色检测胃组织芯片（包括正常胃黏膜、癌旁、非典型增生、原发癌及淋巴结转移癌组织）中Cyclin E蛋白表达。结果Cyclin E在正常胃黏膜组织、非典型增生组织、癌旁组织、原发癌组织和淋巴结转移癌组织的阳性率分别为14．3％、20．0％、34．7％、85．1％和82．9％。与正常胃黏膜、癌旁和非典型增生组织相比，Cyclin E蛋白在原发癌、淋巴结转移胃癌中表达升高（P〈0．01）。结论Cyclin E蛋白可能成为诊断胃癌与淋巴结转移胃癌的分子指标。
Objective This study aimed to investigate the expression of Cyclin E protein in the pro- gress of occurrence and development of gastric cancer and lymphonode metastatic cancer. Methods The expression of Cyclin E protein analyzed by immunohistochemistry in gastric tissue array included of normal gastric mucosa, cancer side tissues, atypical hyperplasia tissues, primary cancer tissues and lymphonode metastatic cancer tissues. Results The positive expression rate of Cyclin E protein was 14. 3% ,20. 0% ,34. 7%, 85.1% and 82. 9% in normal gastric mucosa, atypical hyperplasia tissue, carcinoma side tissue, primary cancer and lymphonode metastatic cancer, respectively. Compared with normal gastric mucosa and carcinoma side tissues and atypical hyperplasia tissues, the Cyclin E protein in primary cancer and lymphonode metastatic carcinoma tissues was over-expression （ P 〈 0. 01 ）. Conclusions The Cyclin E protein was a possible molecular marker that can be used to diagnosis gastric cancer and lymphaden metastasis cancer.
出处
《中国医师杂志》
CAS
2011年第10期1320-1322,共3页
Journal of Chinese Physician
基金
湖南省研究生科研创新项目（CX20108380）
湖南省大学生研究性学习和创新性实验计划项目（CXSY-SJ-09007）
衡阳市课题项目：EB病毒LMP1影响鼻咽癌干细胞SP增殖的分子网络研究（2011KJ53）
