摘要
目的探讨δ-氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣的有效性及治疗前后的病理学改变。方法选择尖锐湿疣初发患者60例,随机分为3组,分别给予光动力治疗、CO2激光治疗、两者联合治疗,记录复发情况和不良反应。光动力治疗组治疗前后行组织病理检查,比较治疗前后炎症程度。结果治疗后复发率光动力治疗组、CO2激光治疗组、联合治疗组分别为20%、55%、10%,各组比较均有统计学意义(P<0.05),联合治疗复发率最低、说明其效果最好,光动力治疗次之,而单纯CO2激光治疗效果欠佳;3组不良反应发生率比较有统计学意义(P<0.05),光动力治疗不良反应发生率最低;光动力治疗前后组织病理切片炎症细胞数量间比较有统计学意义(P<0.05),治疗后较治疗前炎症反应明显加重。结论δ-氨基酮戊酸光动力疗法治疗尖锐湿疣可明显降低复发率,且安全、耐受性好。
Objective To study the therapeutic effect of δ-amino-ketovaleric acid photodynamic therapy（δ-ALA-PDT） on condylomata acuminata and its pathologic changes before and after δ-ALA-PDT.Methods Sixty patients with condylomata acuminata were randomly divided into δ-ALA-PDT group,CO2 laser therapy group,and combined δ-ALA-PDT and CO2 laser therapy group.Recurrence of condylomata acuminata and adverse reactions were recorded.Patients in δ-ALA-PDT group received histopathology examination and their inflammation was compared before and after treatment.Results The recurrence rate of condylomata acuminata in 3 groups was 20%,55% and 10%,respectively（P〈0.05）.The recurrence rate of condylomata acuminata in combined δ-ALA-PDT group and CO2 laser therapy group was the lowest,indicating that the effect of combined δ-ALA-PDT and CO2 laser therapy on condylomata acuminata was the best,followed by δ-ALA-PDT and CO2 laser therapy.The incidence of adverse reactions was the lower in δ-ALA-PDT group than in the other two groups（P〈0.05）.The number of inflammatory cells was significantly less after δ-ALA-PDT than before δ-ALA-PDT（P〈0.05）.The inflammation reaction was severer after δ-ALA-PDT than before δ-ALA-PDT.Conclusion δ-ALA-PDT can significantly reduce the recurrence of condylomata acuminata and is a safe and well-tolerated therapy for condylomata acuminata.
出处
《军医进修学院学报》
CAS
2011年第11期1112-1114,共3页
Academic Journal of Pla Postgraduate Medical School
