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苍术类药材提取物体外对成骨细胞增殖及酶活性的影响 被引量:11

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摘要 目的:观察不同产区苍术的不同提取部位体外对成骨细胞增殖及碱性磷酸酶活性的影响。方法:分别以苍术生药量1×10-4,1×10-6 g.mL-1 2个质量浓度进行新生大鼠成骨细胞、MG-63成骨细胞株增殖和碱性磷酸酶活性测定。结果:茅苍术对大鼠成骨细胞、MG-63成骨细胞株增殖的效果比北苍术好;在挥发油、水煎液、醇提液3个不同提取部位比较中,发现水煎液的效果较好,且道地产区茅苍术的效果最佳,对成骨细胞、MG-63细胞株增殖率分别是11.27%,13.57%;大鼠成骨细胞的ALP活性测定,以茅苍术的水煎液和挥发油的碱性磷酸酶活性最高,均为5.22 U.L-1。结论:苍术类药材对骨质疏松症的治疗有一定的疗效,且茅山地区产茅苍术水煎液对MG-63细胞株、成骨细胞增殖效果最佳。
出处 《中国实验方剂学杂志》 CAS 北大核心 2011年第22期226-229,共4页 Chinese Journal of Experimental Traditional Medical Formulae
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参考文献6

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