摘要
目的:探讨凋亡促进因子Smac/DIABLO和凋亡抑制因子Livin在人乳腺癌组织中的表达及相关性,分析其与乳腺癌转移复发的关系。方法:应用免疫组织化学SP法检测76例乳腺癌组织和相应的癌旁组织中Livin和Smac蛋白的表达情况。结果:76例乳腺癌组织中Livin蛋白表达的阳性率为67.8%(51/76),显著高于相应的癌旁组织的59.2%(36/76),P<0.05;乳腺癌组织中Smac表达为52.6%(40/76),显著低于癌旁组织的75.0%(57/76),P<0.05。两者的表达与组织学分级、肿瘤大小、腋窝淋巴结转移以及术后复发密切相关,P<0.05。Livin和Smac表达呈显著负相关,γ=-0.238,P<0.05。结论:Livin的高表达及Smac/DIABLO的低表达或失活可能在乳腺癌的发生、发展中起重要作用。
Objective：To investigate the expressions of Smac/DIABLO and Livin in breast carcer and their correlation with metastasis and recurrence.Methods： Immunohistochemisty was employed to determine the expressions of Livin and Smac in 76 breast carcinomas and paired adjacent breast tissues.Results： Smac/DIABLO was significantly lower in breast cancer（52.6%,40/76） compared with the paired adjacent breast tissues（75.0%,57/76）（P0.05）and Livin was overexpressed in breast cancers（67.8 %,51/76）compared with the paired adjacent breast tissues（59.2%,36/76）（P 0.05）.The protein expressions of Smac/DIABLO and Livin were significantly correlated with the histological grade diameter of tumour,axillary lymph node metastasis and recurrence of tumor（P 0.05）.There was a significantly negative relationship between Livin and Smac/DIABLO（γ=-0.238,P0.05）.Conclusion： The inactivation of Smac/DIABLO and overexpression of Livin protein might enhance the tumour cell proliferation and malignance and play an important role in progress of human breast cancer.
出处
《现代肿瘤医学》
CAS
2011年第11期2236-2238,共3页
Journal of Modern Oncology
