期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

眼镜蛇毒磷脂酶A_2对兔血小板功能和血液凝固的影响 被引量：1

Effect of Phospholipase A_2 from Naja Naja Atra Venom on Function of Platelet and Blood Coagulation of Rabbit
在线阅读 下载PDF
导出
摘要 眼镜蛇毒磷脂酶A2在体内外均对ADP、花生四烯酸，钙离子载体A23187、血小板激活因子所诱导的兔血小板聚集有显著的抑制作用，并能明显延长血液凝固时间，这些作用均呈剂量一效应关系。 The phospholipase A2 from Naja naja atra venom could inhlbit Platelet aggregation induced by ADP, arachidonic acid, A23187 and PAF in rabbit PRP in vitro and vivo and could increase time of blood coagulation significantly. These actions were dose -edpendent.
作者 罗健东 钟满森
出处 《广州医学院学报》 1995年第5期4-7,共4页 Academic Journal of Guangzhou Medical College
关键词 眼镜蛇毒 磷脂酶A<sub>2</sub> 血小板聚集 血液凝固 Naja naja atra venom phospholipase A_2 platelet aggregation blood coagulation
分类号 R965 [医药卫生—药理学]
  • 相关文献

同被引文献23

  • 1彭新君.眼镜蛇毒磷脂酶A_2研究概况[J].国外医学（中医中药分册）,1996,18(3):16-21. 被引量：1
  • 2Li Feng, Kelly Manabe, Joseph C Shope et al. A real-time fluorogenic phospholipase A2 asssy for biochemical and cellular activity measurements[J].Chemistry and biology, 2002,9:795-803.
  • 3Berg OG, Gelb MH, Tsai MD et al. Interfacial enzymology: the secreted phospholipase A(2)-paradigm[J]. Chem Rev,2001,101(9):2613-54.
  • 4Crofford LJ. Eicosanoids and Other Bioactive Lipid[M]//Tsokos GC ed. Current Molecular Medicine: Principles of Rheumatology, Totowa NJ:Humana Press, 2000:161-73.
  • 5Robin D, jee M, Kumar A. Purification and characterization of an anticoagulant phospholipase A2 from Indian monocled cobra (Naja kaouthia) venom[J]. Toxicon, 2003,41(1):81-91.
  • 6Gu LC, Wang ZQ, Song SY et al. Crystal structures of an acidic phospholipase A2 from the venom of Naja Kaouthia[J]. Toxicon, 2002,40(7):917-22.
  • 7Pan FM, Chao SC, Wu SH et al. Characterization of phospholipase A2(PLA2) from taiwan cobra: Isoenzymes and their site-directed mutants[J]. Biochem Biophys Res Commun,1998, 250(1):154-60.
  • 8Cordella-Miele E, Miele L, Beninati S et al. Transglutaminase-catalyzed incorporation of polyamines into phospholipase A2[J]. Biochem,1993,113(2):164-73.
  • 9Kini RM. Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes[J]. Toxicon,2003,42(8):827-40.
  • 10Lambeau G, Barhanin J, Schweitz H et al. Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom[J]. J Biol Chem,1989,264(19):11503.

引证文献1

二级引证文献8

广州医学院学报
1995年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部