摘要
目的探讨中国非吸烟人群肺癌的危险因素,为防癌措施提供依据。方法采用病例对照研究的方法,按频数匹配收集非吸烟肺癌新发病例306例及非吸烟对照306例,利用统一编制的调查表对调查对象进行面访,收集病例和对照危险因素的暴露史等。结果单因素分析发现25个因素与非吸烟人群肺癌的发病有关联;多因素分析后发现:非吸烟人群肺癌发病的危险因素是体重指数(body mass in-dex,BMI)<18.5,居住地周围有污染企业、装修刺激性气味、家庭被动吸烟、工作场所被动吸烟、使用农药、性格内向、食用油炸食品、肺部手术史、癌症家族史,而保护因素是BMI≥24、常吃蛋类、常吃水果、饮茶、常以散步作为锻炼(2年前),经广义多因子降维法(GWDR)拟合的最优的交互作用模型是居住地企业+装修刺激性气味+家庭被动吸烟+工作场所被动吸烟+农药接触史+癌症家族史。结论非吸烟者发生肺癌的影响因素较多,仍需进一步识别。
Objective To investigate the risk factors for lung cancer among nonsmokers.Methods We performed a case-control study,including 306 cases and 306 controls matched by frequency age（±3 years） and gender.The research population were interviewed to obtain ralated informations using the uniform questionnaire.Results 25 exposure factors were ralated to non-smoking lung cancer by using univariate analysis.The multivariate Logistic regression showed that BMI18.5,polluted factory nearby,irritant smell after decoration,EST exposure at home,EST exposure at work,using pesticide,eating fired food,introversive character,pulmonary-operation history and family history of cancer were risk factors,while BMI≥24,eating egg（3 times/week）and fruit（3 times /week）,drinking tea,frequent exercise（two years ago） might be protective factors.We found there were the most combined effects among polluted factory nearby,irritant smell after decoration,EST exposure at home,EST exposure at work,using pesticide and family history of cancer.Conclusion The risk factors for lung cancer among nonsmokers were complex and need to be further identified.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第11期1306-1310,共5页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金资助项目(30771845
81172766)
福建省科技开发计划资助项目(2005D075)
福建省教育厅科技资助项目(01601065)
