期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

多发性硬化的易感基因最新研究进展 被引量：1

在线阅读 下载PDF
导出
摘要 多发性硬化（Multiple sclerosis,MS）是一种以中枢神经系统白质脱髓鞘为主要病理特点的自身免疫性疾病。多发性硬化的确切病因及发病机制尚未阐明,目前认为可能是遗传易患个体与环境因素（如病毒感染等）相互作用而发生的中枢神经系统自身免疫性疾病。
作者 刘丽娟 吴晓牧
机构地区 江西省人民医院神经内科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2011年第11期1053-1056,共4页 Chinese Journal of Immunology
关键词 多发性硬化 神经系统自身免疫性疾病 易感基因 中枢神经系统 病理特点 发病机制 相互作用 病毒感染
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献37

  • 1O' Connor P. Key issues in the diagnosis and treatment of multiple sclerosis: An overview[J]. Neurology, 2002;59(6 Suppl 3) : sl-33.
  • 2Lincoln M R, Montpetit A, Cader M Z et al. A predominant role for the HLA class Ⅱ region in the association of the MHC region with multiple sclerosis [ J ]. Nat Genet, 2005 ; 37 ( 10 ) : 1108 - 1112.
  • 3Stankovich J, Butzkueven H, Marriott Met al. HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis[J]. Tissue Antigens, 2009 ;74( 1 ) : 17-21.
  • 4Dean G, Yeo T W, Goris A et al. HLA-DRB1 and muhiple sclerosis in Malta[J]. Neurology, 2008 ;70(2) : 101-105.
  • 5Masterman T, Ligers A, Olsson T et al. HLA-DR15 is associated with low- er age at onset in multiple sclerosis [ J ]. Ann Neurol, 2000; 48 (2) : 211- 219.
  • 6Oksenberg J R, Barcellos L F, Cree B A et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans[ J]. Am J Hum Genet, 2004;74( 1 ) : 160-167.
  • 7Silva A M, Pereira C, Bettencourt A et al. The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population [ J ]. J Neurol Sci, 2007; 258 ( 1-2 ) : 69-74.
  • 8Modin H, Olsson W, Hillert Jet al. Modes of action of HLA-DR suscepti- bility specificities in multiple sclerosis [ J ]. Am J Hum Genet, 2004; 74 (6) : 1321-1322.
  • 9Dyment D A, Ebers G C, Sadovnick A D et al. Genetics of multiple scle- rosis [ J ]. Lancet Neurol, 2004 ; 3 ( 2 ) : 104-110.
  • 10Field J, Browning S R, Johnson L Jet al. A polymorphism in the HLA- DPB1 gene is associated with susceptibility to multiple sclerosis [ J]. PLoS One, 2010 ; 5 (10) : 13454-13454.

二级参考文献46

  • 1吕巍,黄蕙芬,印伟,邵杰,赵葆洵.家族性多发性硬化（4例报告）[J].北京医学,1994,16(4):200-202. 被引量：1
  • 2马建军,孙翠萍,赵建华.多发性硬化患者的短潜伏期躯体感觉诱发电位研究[J].中华物理医学杂志,1996,18(2):121-123. 被引量：3
  • 3吕传真,李振新,张华,戚晓昆,臧敬五.中国多发性硬化及相关中枢神经系统脱髓鞘疾病的诊断和治疗专家共识(草案)[J].中华神经科杂志,2006,39(12):862-864. 被引量：56
  • 4王洪林.多发性硬化[A].侯熙德主编.神经病学:第3版[C].北京:人民卫生出版社,1996.156.
  • 5Ota M,Seki T,Fukushima H,et al.HLA-DRB1 genotyping by modified PCR-RFLP method combined with group-specific primers[J].Tissue Antigens,1992,39(4):187-202.
  • 6Masterman T,Ligers A,Olsson T,et al.HLA-DR15 is associated with lower age at onset in multiple sclerosis[J].Ann Neurol,2000,48(2):211-219.
  • 7Ma JJ,Nishimura M,Mine H,et al.HLA-DRB1 and tumor necrosis factor gene polymorphisms in Japanese patients with multiple sclerosis[J].J Neuroimmunol,1998,92(1-2):109-112.
  • 8Yamasaki K,Horiuchi I,Minohara M,et al.HLA-DPB1*0501-associated opticospinal multiple sclerosis:clinical,neuroimaging and immunogenetic studies[J].Brain,1999,12(part9):1689-1696.
  • 9Kira J,Kanai T,Nishimura Y,et al.Western versus Asian types of multiple sclerosis:immunogenetically and clinically distinct disorder[J].Ann Neurol,1996,40(4):569-574.
  • 10Poser CM,Paty DW,Scheinberg L,et al.New diagnostic criteria for multiple sclerosis:guidelines for research protocols[J].Ann Neurol,1983,13(3):227-331.

共引文献29

同被引文献19

  • 1殷宇慧,高枫.家族性多发性硬化两例的临床特点[J].中华神经科杂志,2007,40(11):758-759. 被引量：1
  • 2Freedam MS. Advances in Neurology (Volume 98):Multiple sclerosis and Demyelinating Disease[M].Philadelphia,PA:Lippincott Williams & Wilkins,2006.17-25.
  • 3Kenealy SJ,Babron M C,Bradlford Y. American French multiple sclerosis genetics group.A second generation genomic screen for multiple sclerosis[J].{H}American Journal of Hunan Genetics,2004.1070-1078.
  • 4Baranzini SE,Mudge J,van Velkinburgh JC. Genome,epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis[J].{H}NATURE,2010.1351-1356.
  • 5Stephen S. The complex genetics of multiple sclerosis:pitfalls and prospects[J].{H}BRAIN,2008.3118-3131.
  • 6Baranzini SE,Wang J,Gibson RA. Genome-wide association analysis of susceptibility and clinical phenotype in multiple schrosis[J].{H}Human Molecular Genetics,2009.767-778.
  • 7Sanna S,Pitzalis M,Zoledziewska M. Variants within the immune or egulatory CBLB gene are associated with multiple sclerosis[J].{H}Nature genetics,2010.495-497.
  • 8Jakkula E,Leppa V,Sulonen AM. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene[J].{H}American Journal of Hunan Genetics,2010.285-291.
  • 9Sergio E,Baranzini. Revealing the genetic basis of multiple sclerosis:Are we the yet[J].{H}Current Opinion in Genetics & Development,2011.317-324.
  • 10Weissert R. The immune pathogenesis of multiple sclerosis[J].J Neuroimmune PharmacoL Epub ahead of print,.

引证文献1

二级引证文献2

中国免疫学杂志
2011年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部