摘要
目的:观察CD105和CD146在肺癌组织中的表达,通过计算肺癌组织中微血管密度(MVD)值,探讨CD105和CD146在肺癌的发生、发展及预后的意义。方法:应用免疫组化法观察218例肺癌组织中CD105和CD146的表达。结果:肺癌组织中CD105和CD146的MVD值分别为18.75±4.99和24.63±4.95,明显高于正常肺组织中的8.62±2.40和7.45±2.06,P<0.01。鳞癌组织中CD105和CD146的MVD值分别为13.40±2.47和25.30±4.79,腺癌组织中为7.72±1.77和17.15±4.41;小细胞肺癌组织中为24.27±7.62和35.58±5.84,组间比较差异有统计学意义,P<0.01。结论:CD105和CD146在肿瘤血管生成、发生、发展和转移中起重要作用,并可能成为肿瘤预后判断的参考指标。
ORIECTIVE.. To observe the expression of CD105 and CD146 in lung cancer, and approach their clinical valuation in development and prognosis of lung cancer by comparing microvessel density（MVD）. METHODS： CD105 and CD146 expression was analyzed in 218 samples of lung cancer by immunohistochemistry technology. RESULTS： CD105 and CD146 expression was 18.75±4.99 and 24.63±4.95 in lung cancer respectively, CD105 and CD106 expression was 8. 62±2.40 and 7.45±2.06 in normal pneum-tissue respectively, and the expression of CD105 and CD146 in lung cancer was higher obviously compared with the normal group, with a statistically significant（P〈0. 01）. CD105 and CD146 ex- pression was 13.40~2. 47 and 25. 30--4. 79 in squamous cell carcinoma respectively, 7. 72 ＋ 1.77 and 17. 15 ~ 4. 41 in adenocarcinoma respectively,24.27±7. 62 and 35. 58±5.84 in small cell lung cancer respectively, and there was statistically significant between different groups（P〈0.01）. CONCLUSION： CD105 and CD146 play an important role in tumor angiogenesis, occurrence, development and transfer, and may be the reference index of tumor prognosis.
出处
《中华肿瘤防治杂志》
CAS
2011年第21期1685-1687,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
肺肿瘤
微血管密度
免疫组织化学
预后
lung neoplasms
microvessel density
immunohistochemistry
prognosis
