摘要
目的检测尖锐湿疣（CA）患者治疗前后血清中血管内皮生长因子（vEGF）、缺氧诱导因子-1α（HIF-1α）的表达水平。方法采用酶联免疫吸附法（ELISA）检测40例尖锐湿疣患者治疗前、治疗后2周、治疗后1月血清eVEGF、HIF-1α的表达，并与10例健康人进行比较。结果CA组治疗前血清中VECF的表达水平明显高于健康对照组（P〈0．001），差异具：有统计学意K（P〈0．01）。治疗后2周血清中VEGF比治疗前明显下降（P〈0．01），治疗后1月下降至正常水平，与健康对照组比较差异无统计学意义。CA组治疗前血清HIF-1α的表达水平与健康对照组比较，差异无统计学意义（P〉0．01）；治疗后2月冶疗后1月与治疗前比较，无显著性变化。结论CA皮损组织产生过量的VEGF可能分泌至血液系统中引起血清中VEGF的高水平表达，而HIF-1α不能引起血清中的高水平表达。
Objective To delete the serum expression levels of vascular endothelial growth factor（VEGF） and Hypoxia inducible factor-1α （ HIF-1α ）before and after treatment in condylorna acuaminatum （CA）.Methods The serum expressions of VEGF and HIF-1α in 40 CA patients and 10 normal human were detected by enzyme linked--immunosorbent assay technique （ELISA ）.Results The serum level of VEGF were significantly higher than that in nomal human and significandy reduced after treatment.The serum expression of HIF-1α were not significantly higher than that in nomal human and not significantly reduced after treaunent.Conclusion The over-expression of VEGF in CA tissiu induce high level expression of VEGF in serum. The over-expression ofHIF-1α in CA tissiu does not induce high level expression ofHIF-1 et in serum.
关键词
尖锐湿疣
血管内皮生长因子
缺氧诱导因子-1Α
血清
Condylomata acuminata
Vascular endothelial growth factor
Hypoxia jnducible factor-1α
Serum
