摘要
硬脂酰辅酶A去饱和酶(stearoyl-coenzyme A desaturase,SCD)是催化饱和脂酰辅酶A生成单不饱和脂酰辅酶A的关键酶,在不同的组织中有多种亚型分布。高热量饮食、运动、激素等因素均影响SCD的基因表达水平。对SCD蛋白表达水平和活性的调控会直接影响生物体内饱和脂肪酸(saturated fatty acid,SFA)与单不饱和脂肪酸(monounsaturated fatty acid,MUFA)的比例,从而进一步影响整个机体的脂质代谢,进而与细胞应激反应及胰岛素敏感性直接相关。因此,SCD逐渐成为代谢疾病治疗的一个潜在的靶分子。
Stearoyl-CoA desaturase（SCD） is a key enzyme that catalyzes the saturated fatty acyl-CoAs to unsaturated fatty acyl-CoAs and several SCD isoforms were found in different tissues and organisms.SCD mRNA expression level can be regulated by many factors,such as high calorie diet,excise,and hormones.Regulation of expression and activity of SCD can alter the ratio of monosaturaed fatty acid（MUFA） to saturated fatty acid（SFA）,which can regulate lipid metabolism and further affect cellular stress response and insulin sensitivity.Taken together,accumulated evidence suggests that SCD could be a therapeutic target of metabolic syndrome.
出处
《生命科学》
CSCD
北大核心
2011年第11期1101-1105,共5页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(30871129,30971431)
