摘要
目的观察慢性心力衰竭（CHF）患者血清甲状腺激素（TH）和脑钠肽（BNP）水平的改变及其与心功能的相关性，并分析TH与BNP之间的关系，探讨其在慢性充血性心力衰竭发病机制中的作用。方法选取CHF患者100例（CHF组）和同期健康体检者35例（对照组），采用化学发光免疫法测定血清T3．T4、FT3、FT4、rT3和BNP水平。结果CHF组血清T3、FT3、T3／rT3水平均低于对照组，随心功能不全的加重而逐渐下降（P〈0．05），而血清rT3、BNP水平显著高于对照组，随心功能不全的加重而逐渐升高（P〈0．05）；相关分析显示，CHF患者甲状腺激素T3、rT3、T3／rT3与BNP均呈相关性（P〈0．01）。结论TH、BNP参与心力衰竭的病理生理过程，血清TH、BNP水平反映心脏收缩功能障碍严重程度，可作为评价CHF患者病情严重程度的客观指标。
Objective To investigate the correlation between the changes of the serum thyroid hormone （ TH ）, brain natriuretie peptide（BNP） and cardiac function in patients with chronic heart failure（CHF） ,and analyze the correlation between the levels TH and BNP,then to explore the possible mechanism on CHF. Methods 96 patients suffering from CHF（CHF group） and 30 healthy control subjects（ NC group） in the same time were enrolled. Serum T3 ,T4, FT3, FT4 and BNP were detected by chemoluminescence. Results Serum T3 , FT3 and T3/rT3 were lower in CHF group than those in NC group, and the lower T3 , FT3 ,T3/rT3 levels were, the more serious degree of congestive heart failure would be,which had significant difference（ P 〈 0.05 ） ;while rT3 and BNP levels were higher in CHF group than those in NC group, and the higher T3 , FT3 ,T3/rT3 levels were,the more serious degree of congestive beart failure would be, which had significant difference （P 〈 0. 05 ） ;In patients with CHF, BNP were significantly eorrelated with serum T3 , FT3 and T3/rT3 （P 〈0. 01 ）. Conclusion TH and BNP participate the pathophysiological process of CHF, The changes of sermn TH and BNP levels can be an index of systolic function of heart and prognosis, the serum TH and BNP levels could be the index tot evaluating the state of the illness of patients with CHF.
出处
《浙江临床医学》
2011年第12期1328-1330,共3页
Zhejiang Clinical Medical Journal
关键词
慢性心力衰竭
甲状腺激素
脑钠肽
Chronic heart failure Thyroid hormone Brain natriuretie peptide
