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N-端脑利钠肽前体在重症患者充血性心力衰竭中的应用价值 被引量:16

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摘要 目的探讨N-端脑利钠肽前体(NT-proBNP)在重症患者充血性心力衰竭(CHF)中诊断与病情评估方面的临床应用价值。方法选择42例CHF患者(CHF组)和38例以呼吸困难为主诉并排除心脏疾病患者(对照组),入住重症加强治疗病房时测定两组患者的血浆NT-proBNP浓度和左室射血分数(LVEF),CHF组患者行肺动脉漂浮导管置管测定心脏指数(CI)和肺毛细血管楔嵌压(PCWP)。结果 CHF组血浆NT-proBNP浓度显著高于对照组,LVEF显著低于对照组,差异均有统计学意义(P<0.01)。CHF组患者中,不同NYHA心功能分级、不同LVEF分级、不同Forrest血流动力学分级的各亚组患者血浆NT-proBNP浓度间差异均有统计学意义(P<0.05);血浆NT-proBNP浓度分别与LVEF、CI之间呈负相关(P<0.05)。结论血浆NT-proBNP水平能较好地反映重症患者左室功能状态,有助于重症患者CHF的诊断与病情评估。
出处 《广东医学》 CAS CSCD 北大核心 2011年第23期3094-3096,共3页 Guangdong Medical Journal
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参考文献12

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