摘要
目的:探讨胃癌螺旋CT(SCT)征象与磷酸酶基因(PTEN)表达之间的潜在联系,以及与临床病理的相关性。方法:选择进展期胃癌患者60例,术前一周进行SCT三期增强扫描,术后标本分别进行HE染色读片及免疫组化染色SP法检测PTEN表达。结果:SCT示浆膜侵犯判断的准确性为91.66%(55/60),淋巴结转移判断准确性为78.95%(45/57),远处转移判断准确性为100%(4/4),其中4例远处转移者均伴有淋巴结转移。SCT诊断浆膜侵犯(T3+T4)和淋巴结转移(包括远处转移)与病理诊断显示较好的一致性(P值分别为0.00013和0.00011)。按螺旋CT的诊断结果,浆膜无侵犯病例PTEN阳性表达率为75%,明显高于浆膜有侵犯病例的27.08%(P<0.05);淋巴结无转移病例PTEN阳性表达率为100%,明显高于淋巴结有转移病例的33.33%(P<0.05);无远处转移病例PTEN阳性表达率为39.29%,4例有远处转移病例PTEN阳性表达率为0,两组有显著性差异(P<0.05)。结论:PTEN是预测胃癌细胞转移潜能的重要生物学指标,PTEN低表达的胃癌患者具有更高的转移倾向,而SCT征象与肿瘤细胞PTEN的表达密切相关,临床可以通过SCT征象无创性地推测胃癌的生物学特性,从而对胃癌的侵袭、转移和预后作出合理的评估,指导临床制定合理的治疗方案。
Objective To evaluate the potential link between spiral CT（SCT） signs and PTEN expression in gastric cancer and the correlation with clinicopathology.Methods Sixty patients with advanced gastric cancer were selected.SCT three-phase enhanced scan was conducted on them a week before surgery.HE staining,smearing and SP immunohistochemical staining were conducted on specimens after surgery to detect PTEN expression.Results SCT showed the accuracy of determining serosal invasion was 91.66%（55/60）,that of determining lymph node metastases was 78.95%（45/57）,and that of determining distant metastases was 100%（4/4）,of which,four patients with distant metastases combined with lymph node metastases.SCT diagnosis and pathological diagnosis of serosal invasion（T3 ＋ T4） and lymph node metastasis（including distant metastasis） showed a good consistency（P values were 0.00013 and 0.00011,respectively）.Diagnosed by SCT,the positive rate of PTEN expression in patients with no serosal invasion was 75.00%,significantly higher than that（27.08%） of patients with serosal invasion（P0.05）;that of patients with no lymph node metastasis was 100.00%,significantly higher than that（33.33%） of patients with lymph node metastasis（P0.05）;that of patients with no distant metastasis was 39.29%,and of 4 patients with distant metastasis,the two groups showed significant differences（P0.05）.Conclusion PTEN is an important biological indicator to predict the metastatic potential of gastric cancer cells.Gastric cancer patients who have low PTEN expression possessed a higher metastatic potential,while SCT signs is closely related to PTEN expression in tumor cells.Clinically,biological characteristics of gastric cancer can be speculated by SCT signs noninvasively,and thus a reasonable assessment is conducted on the invasion,metastasis and prognosis of gastric cancer to guide and develop rational treatment plans.
出处
《放射免疫学杂志》
CAS
2011年第6期676-678,共3页
Journal of Radioimmanology
基金
浙江省玉环县科技计划项目(项目编号:200734)
关键词
胃癌
螺旋CT
磷酸酶基因
gastric cancer
spiral CT
phosphatase and tersin homology deleted on chromosome ten（PTEN）
