摘要
目的:探讨新辅助化疗应用于局部晚期宫颈癌的临床疗效。方法:选择Ⅰb2～Ⅱb期的宫颈癌患者52例。术前根据癌细胞病理分型,予以联合方案化疗2～3个周期,然后行广泛性子宫切除术和盆腔淋巴结清扫术。结果:52例患者术前化疗后,患者症状、体征均有明显改善,为根治性手术治疗创造了有利条件,临床总有效率92.5%,手术率88.50%(46/52)。结论:局部晚期宫颈癌术前新辅助化疗可以明显改善临床症状、缩小肿瘤的体积或侵及范围、降低肿瘤临床分期,提高手术率,降低高危因素、降低复发率,有望提高5年存活率。
Objective： To investigate the clinical efficacy of neoadjuvant chemotherapy used for locally advanced cervical cancer patients.Methods： Total 52 cases of Ⅰb2～ Ⅱb cervical cancer were included.According to pathological types of the cancer cells,2 to 3 cycles of combined chemotherapy were used before surgery,then extensive hysterectomy and pelvic lymph node dissection would be done.Results： After preoperative chemotherapy,symptoms and signs of all patients were significantly improved,it created favorable conditions for the radical surgery,total clinical effective rate was 92.5%,and surgery rate was 88.50%（46/52）.Conclusion： The use of neoadjuvant chemotherapy for the locally advanced cervical cancer before surgery can alleviate clinical symptoms significantly,reduce size as well as the invaded area of the tumor,lower clinical stage and improve the surgery rate,reduce risk factors and the relapse rate,and it can be expected to extend 5-year survival.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2011年第11期1656-1659,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
宫颈癌
新辅助化疗
手术率
cervical cancer
neoadjuvant chemotherapy
surgery rate
