摘要
目的总结我国2010年门诊患者分离细菌的分布与耐药状况。方法监测2010年度卫生部全国细菌耐药监测网所属医院临床分离细菌耐药状况,采用标准纸片扩散法或自动化临床微生物测定方法,测定细菌敏感性,依据CLSI2010年标准,用WHONET 5.6软件进行数据分析。结果按照监测方案129所医院共获得临床分离菌17002株。其中,革兰阴性菌10009株(占58.9%);革兰阳性菌6993株(占41.1%)。耐甲氧西林金黄色葡萄球菌及凝固酶阴性葡萄球菌检出率分别为30.9%和73.1%;未发现万古霉素耐药葡萄球菌。粪肠球菌和屎肠球菌对万古霉素耐药率分别为0.3%和0.7%;未发现利奈唑胺耐药肠球菌。有2.4%的大肠埃希菌和4.5%的肺炎克雷伯菌对亚胺培南耐药。铜绿假单胞菌对碳青酶烯类的耐药率接近20%,与去年相近;鲍曼不动杆菌对米诺环素耐药率为20.1%,对头孢哌酮/舒巴坦耐药率为26.4%,对其他抗菌药物耐药率为50%～75%。结论我国门诊来源分离菌株较去年增加近1倍,耐药情况与上一年度相似,需引起重视。
Objective To explore the bacterial drug resistance and its epidemic trend in outpatients in China for clinical reference in the use of antibacterial agents. Methods All of the bacterial susceptibility results from 129 tertiary care hospitals in Mohnarin from Jan 1 to Dec 31, 2010 were collected by unified protocol and the data were analyzed by software WHONET 5.6. The disc - diffusion or automatic clinical microbiological system method was used for the bacterial sensitivity. Results A total of 17002 bacterial isolates and their antibacterial susceptibility data were collected during the survey period in 129 hospitals, which included 10009 （58.9%） Gram - negative bacterial strains and 6993 （41.1%） Gram - positive bacterial strains. The incidences of methicillin - resistant S. aureus （ MRSA ） and coagulase negative Staphylococcus （ MRSCN ） were 30. 9% and 71.1%, respectively. No vancomycin resistant Staphy- lococcus strains were found. There were 0. 3% of Enterococcus faecalis and 0. 7% of Enterococcusfaecium resistant to vancomycin. No linezolid resistant Enterococcus strains were found. Isolates of Enterobacteriaceae were still highly sensitive to imipenem and meropenem. The average resistance rates were less than 5%. About 20% of P. aeruginosa strains were resistant to the two carbapenems. 20. 1% and 26.4% of A. baumannii were resistant to minocycline and cefoperazone - sulbactam, Conclusion Bacterial resistance in outpatients was common and bacterial year.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2011年第12期899-904,912,共7页
The Chinese Journal of Clinical Pharmacology
关键词
门诊患者
细菌耐药
监测
outpatients
bacterial resistance
surveillance while 50% -75% resistance rate was to the other drugs. similar to that in last
