摘要
目的:探讨莫西沙星序贯疗法在社区获得性肺炎中的应用效果。方法:将60例住院社区获得性肺炎患者按抛硬币分组法分为对照组(28例)与研究组(32例)。两组患者的疗程7～14d,对照组静脉连续点滴左氧氟沙星(500mg),1次/d;研究组静脉连续点滴莫西沙星注射液(0.4g),1次/d,序贯治疗后改为口服莫西沙星片(0.4g),1次/d。评价两组的临床疗效和住院费用。结果:研究组总有效率为93.75%,明显高于对照组(71.42%),差异有统计学意义(χ2=5.36,P<0.05)。研究组的细菌清除率95.57%,明显高于对照组(77.78%),差异有统计学意义(χ2=6.35,P<0.05)。研究组住院时间及住院总费用为(8.42±3.18)d及(4628.6±587.9)元,明显少于对照组(11.17±2.34)d和(5868.4±612.5)元,差异具有统计学意义(t值分别为3.77,7.99;P<0.01)。结论:莫西沙星序贯疗法治疗社区获得性肺炎具有较好的临床疗效,还能减少住院时间和住院费用,具有较好的临床应用价值。
Objectlve：To explore the application effect of Moxifloxacin sequential therapy on Community - acquired pneumonia. Methods：In- patients who was Community -acquired pneumonia（CAP） were divided into the study group （32 cases） and control group （28 cases） in accordance with the method of dividsion into groups of Toss a coin. The course of treatment of two groups was 7 ~ 14 days, the control group were given continuous intrave- nous drip Levofloxacin （500rag） once a day, the study group were given continuous intravenousdrip injection of Moxifloxacin （0.4g） once a day, after the sequential therapy was carried out, they took orally troche Moxiftoxacin （0.4g） once a day. After they left the hospital, the clinical effece and the hospital expenses of two groups were evaluated. Results：The total effective rate（93.75% ） of the study group was higher than the total effective （71.42%） of the control group （ X2 = 5.36, P 〈 0.05 ）. The bacterial clearance rate （ 95.57 % ） of the study group was higher than the bacterial clearance rate （ 77.78 % ） the control group（ X2 = 6.35 ,P 〈 0.05）. The hospitalization time（ 8.42 ~ 3.18 ）d and the hospital expenses （4628.6 ~ 587.9 ）yuan of the study group were lower than the hospitalization time （1.17 ~ 2.34）d and the hospital expenses （5868.4 ~ 612.5 ）yuan of the control group （t value were sparately 3.77,7.99, P 〈 0.01 ）. Conclusion ：The Moxifloxacin sequential therapy wich treated CAP had better clinineal effect, and it could reduce hospitalization time and hospital expenses. It had bettter clinincal anvlieation effect.
出处
《中国民康医学》
2011年第24期3012-3014,共3页
Medical Journal of Chinese People’s Health
关键词
社区获得性肺炎
莫西沙星
序贯疗法
Community - acquired pneumonia
Moxifloxacin
Sequential therapy
