摘要
目的 探讨CD15和P5 3表达与子宫内膜腺癌侵袭和转移的关系。方法 应用SP免疫组化法对 40例原发性子宫内膜腺癌组织进行了CD15和P5 3检测。结果 CD15和P5 3在子宫内膜腺癌中阳性率分别为 72 .5 %和 6 5 .0 %。CD15和P5 3表达与子宫内膜腺癌的分级、分期和转移相关 (P <0 .0 5 ) ;CD15表达与P5 3表达呈正相关。结论 CD15和P5 3表达对判断子宫内膜腺癌的恶性程度、预测肿瘤侵袭转移和评估预后是一种良好指标。
? Objective To investigate the relationship between the expression of CD15 antigen and P53 and carcinogenesis,progression and metastasis of endometrial carcinoma.Methods The expression of CD15 and P53 in 40 cases of endometrial adenocarcinoma was detected by SP immunohistochemical technique.Results The positive rate of CD15 and P53 was 72.5% and 65.0% respectively.CD15 and P53 were correlated with the histologic grading and clinical staging of endometrial adenocarcinoma and correlated with metastases (P<0.05).The expression of CD15 was positively correlated with the expression of P53.Conclusions These findings demonstrate that the positive expression of CD15 and P53 in endometrial adenocarcinoma are useful markers to evaluate the degree of malignancy and biological behavior for tumors,which can also predict the prognosis of patients. 〔
出处
《中国肿瘤临床与康复》
2000年第1期28-29,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
