摘要
目的评价高频超声心动图在阿霉素(ADM)造模大鼠心力衰竭研究中的价值。方法 30只SD大鼠随机分成对照组、ADM组。大鼠尾静脉注射ADM制成心力衰竭模型。对两组大鼠行经胸高频超声心动图监测。分别取两组大鼠的心肌组织行HE染色及VG染色。结果高频超声心动图可以清晰显示大鼠的心脏结构,经超声测定ADM组与对照组心功能变化比较差异有统计学意义(P<0.01)。经高频超声心动图所证实的心力衰竭大鼠,HE染色及VG染色结果均证实其心肌组织明显受损。结论经胸高频超声心动图可以无创、准确地评价ADM造模大鼠心功能的改变,与病理结果一致。
Objective To assess the effect of high frequency echocardiography on cardiac failure of rats produced by adriamycin （ADM, doxorubicin）. Methods 30 SD rats were randomly divided into control group and ADM group. The model of cardiac failure of rats was made by injecting ADM into their tail veins. Then we observed two groups of rats with high frequency echocardiography. The myocardiac tissue of rats was observed by HE staining and VG staining method. Results High frequency echocardiography could reveal vividly the structure of rats＇ hearts. There was statistical significance between the normal control group and the ADM group in the changes of heart function which was concluded by high frequency echocardiography （P 〈 0.01 ）. The results of HE staining and VG staining of rats＇ myocardiac tissue also proved that there was obviously injury. Conclusion High frequency echocardiography is an accurate and noinvasive method in assessing the changes of heart function of rats, and it is in according with phathology.
出处
《安徽医科大学学报》
CAS
北大核心
2012年第1期20-23,共4页
Acta Universitatis Medicinalis Anhui
关键词
超声心动图
心力衰竭
左心室功能
阿霉素
echocardiography
left ventricular function
heart failure
doxorubicin
