摘要
目的分析2007年—2009年我院铜绿假单胞菌多重耐药(multidrug resistant,MDR)菌株对多种抗菌药物的耐药性变迁。方法收集2007年1月—2009年12月我院细菌室分离的铜绿假单胞菌,采用琼脂扩散法作敏感试验。结果 3年来共分离铜绿假单胞菌422株,其中MDR菌株100株,占23.70%。分离出的MDR菌株分布在呼吸科普通病房(13.00%)、呼吸重症监护病房(RICU)(29.00%)、外科病房(9.00%)、外科监护病房(SICU)(20.00%)、急诊科(5.00%)和其他内科病房(14.00%)。各科室中,分离出的MDR菌株数占所有标本分离的该菌株数的比例最高的是RICU(42.39%,39/92),其次为SICU(37.04%,20/54)。痰标本分离的MDR菌株占76.00%(76/100),其次为尿液(5.00%,5/100)。铜绿假单胞菌MDR菌株的分离率在3年期间无显著性差异。3年期间铜绿假单胞菌MDR菌株对头孢哌酮/舒巴坦耐药率最低(分别为25.00%、37.93%、40.48%);对所有检测的抗菌药物耐药率各年间无显著性差异。RICU与SICU分离的MDR菌株对亚胺培南、美罗培南耐药率显著高于其他普通病房,对其余检测的抗菌药物耐药率与其他病房无显著性差异。结论我院铜绿假单胞菌MDR菌株的耐药情况近年来十分严峻,在RICU与SICU,MDR菌株对碳青霉烯类耐药尤其严重,因此需严密监测细菌耐药性,指导合理使用抗菌药物。
Objective To analyze the changing pattern of antimicrobial resistance of multidrug resistant （MDR） Pseudomonas aeruginosa during 2007-2009. Methods Strains of P. aeruginosa isolates from January 2007 to December 2009 were collected. Antimicrobial susceptibility of clinical isolates was tested by Kirby-Bauer method. Results A total of 422 P aeruginosa were collected during 3 years, among which 100 isolates were MDR strains （23.70%）. Of the MDR strains, 13 strains （13.00 %） were from respiratory unit, 29 strains （29.00%） from respiratory intensive care unit （RICU）, 9 strains （9.00 %） from surgical units, 20 strains （20.00%） from surgical intensive care unit （SICU）, 5 strains （5.00 %） from emergency units, 14 strains （14.00%） from other medical units. Among all units, the percentage of the MDR stains to whole P aeruginosa stains collected was the highest in RICU （42.39%, 39/92 ）, then SICU （37.04%, 20/54 ）. Most strains （76.00%） were isolated from sputum, then urine （5.00%, 5/100）. The prevalences of MDR P. aeruginosa during the three years were similar. From 2007 to 2009, the resistance rates of MDR P. aeruginosa to cefoperazone / sulbactam were the lowest （25.00%, 37.93% and 40.48%, respectively）; the resistance rates to all tested antimicrobial agents had no significant differences during theses years. The resistance rates of MDR strains isolated from RICU and SICU to imipenem, meropenem were much more higher than those of strains isolated from other units, while which to other antimicrobial agents were similar to those from other units. Conclusions The condition of antimicrobial resistance of MDR P. aeruginosa was quite severe in our hospital in recent years, especially the resistance rates of MDR strains isolated from RICU and surgical ICU to carbapenems were much more higher than other units, so antimicrobial resistance surveillance should be strengthened to direct rational use of antibiotics.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2012年第1期63-67,共5页
Chinese Journal of Antibiotics
关键词
铜绿假单胞菌
多重耐药
耐药性
抗菌药物
Pseudomonas aeruginosa
Multidrug resistant strains
Antimicrobial resistance
Antimicrobial agents
