摘要
目的了解新生儿重症监护病房(NICU),呼吸机相关性肺炎(VAP)病原菌构成与耐药性,为临床合理选用抗菌药物提供依据。方法对NICU 2009年3月-2010年2月27例VAP的患儿进行病原菌分布和临床特征的调查。结果 36株临床分离病原菌中,革兰阴性杆菌占88.89%,革兰阳性球菌占8.33%,真菌占2.78%;主要致病菌为鲍氏不动杆菌占38.89%、肺炎克雷伯菌占13.89%、嗜麦芽寡养单胞菌占13.89%,对头孢哌酮/舒巴坦敏感性好。结论 NICU的VAP病原菌以革兰阴性杆菌为主,开展病原菌耐药性监测,对指导临床合理选择抗菌药物具有重要参考价值。
OBJECTIVE To investigate the proportion of pathogenic bacteria and their pathogen resistance in Ventilator-Associated Pneumonia （VAP） in Neonatal Intensive Care Unit （NICU）, which could provide evidence for clinically reasonable administration of antibacterial agents. METHODS A total of 27 patients with VAP in NICU from Mar 2009 to Feb 2010 were analyzed for the bacterial distribution and clinical characteristics. RESULTS Of the 36 clinical isolates, 88.89% were Gram-negative bacilli, 8.33% were Gram-positive cocci, and 2.78% were fungi . The major pathogenic bacteria included Acinetobacter baumannii （38.89 %）, Klebsiella pneumoniae （13. 89%）, Stenotrophomonas maltophilia （13. 89%）, and all of them were highly susceptible to eefoperazone/sulbactam. CONCLUSION Gram-negative bacilli are the majority of the pathogens from infants with VAP in NICU. It is important to carry out surveillance of resistant pathogens, which will provide great reference value for the rational selection of antibiotics in clinical practice.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第1期182-184,共3页
Chinese Journal of Nosocomiology
基金
浙江省康恩贝医院管理软科学研究项目(2009AZHA-KEB103)
