摘要
目的了解医院儿科患者产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌耐药性变化情况,为临床合理选用抗菌药物提供依据。方法按照NCCLS标准操作,用头孢噻肟、头孢噻肟/克拉维酸等药敏纸片以扩散法检测,样本为2010年1-12月分离的肺炎克雷伯菌,对其产ESBLs肺炎克雷伯菌耐药率与2008年进行比较。结果 2010年1-12月分离的产ESBLs肺炎克雷伯菌占57.2%,而2008年为36.8%,差异有统计学意义(P<0.05),产ESBLs肺炎克雷伯菌,对氨曲南敏感率2010年为19.3%,而2008年为47.8%,呈显著下降(P<0.05),磺胺甲噁唑/甲氧苄啶及利福霉素仍保持较高的敏感率,3年差异无统计学意义,亚胺培南对产ESBLs肺炎克雷伯菌仍100.0%敏感。结论近年儿科产ESBLs肺炎克雷伯菌检出数及检出率均有明显增加,耐药性也明显增加,应加强儿科抗菌药物使用的管理。
OBJECTIVE To investigate the change of drug resistance of extended-spectrum β-lactamases（ESBLs）-producing Klebsiella pneumoniae from pediatric patients,to provide evidence for clinical reasonable use of antibiotics.METHODS In accordance with the NCCLS standard operating,cefotaxime,cefotaxime/clavulanic acid susceptibility disk diffusion method was used to isolates of test the hospital from Jan 2010 to Dec 2010 of ESBLs prodcing and their resistance of K.pneumoniae were compared with 2008.RESULTS From Jan.to Dec.2010,the isolated ESBLs-producing K.pneumoniae accounted for 57.2%,36.8% in 2008,the difference was significant（P〈0.05）.The susceptibility rate of ESBLs-producing K.pneumoniae to aztreonam was 19.3% in 2010,47.8% in 2008,presenting a significant decrease（P〈0.05）.ESBLs-producing K.pneumoniae maintained high susceptibility to sulfamethoxazole/trimethoprim and rifamycin,there was no significant change during the three years.ESBLs-producing K.pneumoniae remained the susceptibility rate of 100.0% to imipenem.CONCLUSION In recent years,ESBLs-producing K.pneumoniae shows a significant increase both in number and the detection rate as well as the drug resistance,management of antibiotic use in department of pediatrics should be further strengthened.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第2期412-413,共2页
Chinese Journal of Nosocomiology
基金
徐州市科学技术委员会计划项目(XZZD0901)
关键词
超广谱Β-内酰胺酶
肺炎克雷伯菌
检测
耐药性
Extended spectrum β-lactamase
Klebsiella pneumoniae
Detection
Resistance
