期刊文献+

Hcy与PCOS血管病变及胰岛素抵抗研究进展

在线阅读 下载PDF
导出
摘要 多囊卵巢综合征(PCOS)是最常见的妇科内分泌疾病之一, PCOS临床特点有:月经稀发或闭经、不孕、肥胖、多毛、痤疮、黑棘皮症、卵巢增大呈多囊性改变.远期并发症:心血管疾病、糖尿病、子宫内膜癌等.随着环境污染的日渐加重及生活方式改变,近年来PCOS发病率呈越来越高的趋势,约为5%~10%.PCOS与高血压和2型糖尿病的发病密切相关,超过30%的非肥胖和75%的肥胖妇女有高胰岛素血症与PCOS[1].
出处 《医学临床研究》 CAS 2011年第12期2340-2342,共3页 Journal of Clinical Research
  • 相关文献

参考文献21

  • 1Legro RS,Kunselman AR,Dunaif A.Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome[J].Am J Med,2001,111(8):607-613.
  • 2Kilicdag EB,Bagis T,Tarim E,et al.Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin:a randomized trial[J].Hum Reprod,2005,20(6):1521-1528.
  • 3Wild RA,Painter PC,Coulson PB,et al.Lipoprotein lipid concentrations and cardiovascular risk in patients with polycystic ovary syndrome[J].Clin Endocrinol Metab,1985,61(5),946-951.
  • 4Gonzalez F.Evidence of proatherogenic inflammation in polycystic ovary syndrome[J].Metabolism,2009,58(7):954-962.
  • 5Zwirska-Korczala K.Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome[J].J Physiol Pharmacol,2008,59(Suppl 2):161-178.
  • 6Schachter M.Insulin resistance in patients with polycystie ovary syndrome is associated with elevated plasma homoeysteine[J].Hum Reprod,2003,18(4):721.
  • 7Vrbikova J,Tallova J,Bicikova M,et al.Plasma thiols and androgen levels in polycystic ovary syndrome[J].Clin Chem Lab Med,2003,41(2):216-221.
  • 8Pierpoint T,McKeigue PM,Isaacs AJ,et al.Mortality of women with polycystic ovary syndrome at long-term follow-up[J].Clin Epidemiol,1998,51(7),581-586.
  • 9Yilmaz M,Bukan N,Ersoy R,et al.Glucose intolerance,insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndrome[J].Hum Reprod,2005,20(9):2414-2420.
  • 10李瑜,张向阳.高同型半胱氨酸血症导致血管内皮细胞功能损伤机制的研究进展[J].新疆医科大学学报,2009,32(5):654-656. 被引量:13

二级参考文献28

  • 1Neil Kaplowitz.Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury[J].World Journal of Gastroenterology,2004,10(12):1699-1708. 被引量:65
  • 2任立群,王金凤,李永梅,张秀云,李广生.同型半胱氨酸对血管平滑肌细胞基质金属蛋白酶1及金属蛋白酶组织抑制剂1的影响(英文)[J].中国组织工程研究与临床康复,2007,11(27):5455-5457. 被引量:2
  • 3Lee SJ, Kim KM, Namkoong S, et al. Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of Snitrosohomocysteine [ J ]. J Biol Chem, 2005, 280 ( 7 ) :5781-5788.
  • 4Alvarez-Maqueda M, El Bekay R, Monteseirin J, et al. Homocysteine enhances superoxlde anion release and NADPH oxidase assembly by human neutrephils. Effects on MAPK activation and neutrophil migration[ J]. Atherosclerosis, 2004, 172(2) :229-238.
  • 5Wassmann S, Laufs U, Mailer K. Cellular antioxidant effects of atorvastatin in vitro and in vivo[J]. Arterioscler Thromb Vase Biol, 2002, 22 (2) : 300-305.
  • 6Ten Freyhaus H, Huntgeburth M, Wingler K. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation[J]. Cardiovasc Res, 2006, 71 (2) :331- 341.
  • 7Mohsen Kerkenl, Mehdi Tnani, Laurence Chuniaud, et al. Comparative study on in vitro effects of homocysteine thiotactone and homocysteine on HUVEC cells : Evidence for a stronger proapoptotic and proinflammative homocysteine thiolactone [ J ]. Mol Cell Biochem, 2006, 291 (1-2) :119-126.
  • 8Au-Yeung KK, Woo CW, Sung FL, et al. Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress[ J]. Circ Res ,2004,94( 1 ) :28-36.
  • 9Rubba P. Effects of atorvastatin on the different phases of atherogenesis[J]. Drugs, 2007, 67(Suppll ) :17-27.
  • 10Goettsch C, Goettsch W, Muller G. Noxg overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells [J]. Biochem Biophys Res Commun, 2009, 380(2) :355-360.

共引文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部