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DJ-1在肿瘤中作用的研究进展 被引量：6

Role of DJ-1 gene in tumors
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摘要 DJ-1基因是一种新的线粒体依赖癌基因。当前在帕金森病领域,对DJ-1基因的研究较多,认为其与人类家族性早发型帕金森病相关。近来研究发现DJ-1基因与人类多种恶性肿瘤的发生、进展及预后等密切相关,可作为癌症发生的预警标志物,但也有DJ-1在肿瘤中低表达的报道。 The DJ-1 gene is a novel mitogen-dependent oncogene.It has been studied extensively in early-onset familial forms of Parkinson disease（PD）.Recent studies found that DJ-1 is related to the occurrence,development and prognosis of some kinds of human malignant neoplasms and may serve as a prognostic marker.However,there is also evidence to show low-expression of DJ-1 in tumor cells.
作者 王娟 谭晖 苏琦
机构地区 南华大学肿瘤研究所
出处 《国际病理科学与临床杂志》 CAS 2011年第6期527-530,共4页 Journal of International Pathology and Clinical Medicine
关键词 DJ-1 肿瘤 自体吞噬 DJ-1 neoplasms autophagy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

  • 1Taira T, Takahashi J, Kitagawa R, et al. Molecular cloning of human and mouse DJ-1 genes and identification of Spl-dependen- tactivation of the human DJ-1 promoter[J]. Gene,2001,263( 1/ 2 ) :285-292.
  • 2Annesi G, Savettieri G, Pugliese P, et al. DJ-I mutations and par- kinsonismlementia-amyotrophic lateral sclerosis complex [ J ]. Ann Neuro1,2005,58 ( 5 ) : 803-807.
  • 3Martinat C, Shendelman S, Jonason A, et al. Sensitivity to oxida- tive stress in DJ-1--deficient dopamine neurons: an ES:terived cell model of primary parkinsonism [ J ]. PLoS Biol, 2004, 2 ( 11 ) : 1755-1763.
  • 4Junn E, Taniguchi H, Jeong BS, et al. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death[J]. Proc Nad Acad Sci U S A, 2005, 102(27) : 9691- 9696.
  • 5Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson' s disease and other age-related disorders [J ]. Free Radic Biol Med, 2009, 47(10) :1354-1361.
  • 6Pardo M, Garcla A, Thomas B, et al. The characterization of the in- vasion phenotype of uveal melanoma tumor cells shows the pres- ence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker [ J ]. Int J Cancer,2006,119 ( 5 ) : 1014-1022.
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  • 8吴芳,梁瑛琦,黄智铭.DJ-1基因在肝细胞癌中的表达及其与肝癌侵袭和转移的关系[J].中华肝脏病杂志,2009,17(3):203-206. 被引量：12
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  • 10秦慧,刘霆,杨金亮,黄欣,柳斌,宋鑫,赵霞,魏于全.蛋白质组学方法筛选维甲酸耐药相关蛋白[J].中华医学杂志,2007,87(8):520-525. 被引量：8

二级参考文献30

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二级引证文献16

国际病理科学与临床杂志
2011年 第6期

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