摘要
背景:表皮干细胞以显著的自我更新和多向分化潜能及皮肤组织工程学中诱人的应用前景,作为"种子细胞"成为皮肤创伤研究领域的热点之一。目的:综述表皮细胞去分化逆转为表皮干细胞的研究近况。方法:应用计算机检索1998-01/2011-01PubMed、Highwire和中国期刊全文数据库相关文章,检索词"dedifferentiation,epidermalcells,epidermalstemcells,induction,去分化,表皮细胞,表皮干细胞,诱导"。共检索到文献2754篇,最终纳入符合标准的文献46篇。结果与结论:去分化来源的表皮干细胞与机体自身来源的表皮干细胞之间在形态学和功能有许多相似点,并可表达表皮干细胞的特异性标记物。表皮细胞去分化途径制造表皮干细胞,可以作为机体自身来源表皮干细胞的替代细胞应用于皮肤损伤重建和再生的相关研究,为实现皮肤创伤由解剖修复到功能修复的"完美修复"提供新思路。
BACKGROUND：Epidermal stem cells as seed cells have been paid great attention on the research of wound repair and regeneration with its specific biological advantages with the development of molecular biology and bioengineering.OBJECTIVE：To review the recent advances in the mature epidermal cells dedifferentiating towards epidermal stem cells.METHODS：The first author retrieved PubMed database,Highwire database（Highwire.standford.edu） and CNKI for articles published from January 1998 to January 2011.The keywords were ＂dedifferentiation,epidermal stem cell,epidermal cell,induction＂ in English and Chinese.A total of 2 754 literatures were collected,and finally 46 papers were included in result analysis.RESULTS AND CONCLUSION：The dedifferentiated epidermal stem cells have some characteristics of native epidermal stem cells and perhaps they may act as a new vehicle for wound repair and regeneration.Both of the native epithelial stem cells and the dedifferentiated epithelial stem cells can promote the wound repair and their effects were on the same level.Because differentiation from epidermal cells into epidermal stem cells has many questions,so far,there are many animal researches,but its extensive clinical application deserves further development.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第49期9295-9298,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
