摘要
目的:研究注射用奥美拉唑钠在7种溶剂中的配伍稳定性。方法:将40 mg奥美拉唑加入0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、果糖、5%碳酸氢钠溶液、10%葡萄糖酸钙溶液、25%硫酸镁溶液中,用高效液相色谱法测定配伍后的奥美拉唑钠的含量,并测定其pH值及观察液体变化,观察温度对0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液中奥美拉唑钠颜色的影响。结果:注射用奥美拉唑钠与7种溶剂配伍后,其中0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液在1 h内未出现颜色的变化,但放置3 h后5%葡萄糖注射液、10%葡萄糖注射液的液体由无色变为淡黄色,而果糖、10%葡萄糖酸钙及25%硫酸镁溶液30 min后即出现了颜色的变化以及沉淀。在37℃下,5%葡萄糖注射液、10%葡萄糖注射液在1 h内就出现了颜色变化。结论:奥美拉唑钠可以与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍,其中以0.9%氯化钠注射液最佳,但与5%葡萄糖注射液、10%葡萄糖注射液配伍要注意温度以低于25℃为宜,放置时间不宜超过2 h,而果糖、10%葡萄糖酸钙溶液、25%硫酸镁溶液与奥美拉唑钠配伍禁忌。
OBJECTIVE： To observe the compatible stability of omeprazole sodium for injection in seven solvents.METHODS： 40 mg omeprazole was added into different solvents（0.9% NS,5% GS,10% GS,fructose,5% bicarbonate sodium,10% calcium gluconate solution or 25% magnesium sulfate solution）,then the stability of the mixtures was determined by high-performance liquid chromatography（HPLC）,and their pH values was determined as well and the appearance of omeprazole sodium after being added to 0.9% NS,5% GS or 10% GS were observed.RESULTS： Within 1 hour after mixing with 0.9% NS,5% GS or 10% GS,omeprazole sodium showed no change in appearance;however,3 hrs after mixing with 5% GS or 10% GS,the appearance of the omeprazole sodium mixture turned from colorless to yellowish;30 min after mixing with fructose,10% calcium gluconate or 25% magnesium sulfate solution,omeprazole sodium mixture presented with color change and sediments.At 37 ℃ within 1 hour after mixing respectively with 5% GS or 10% GS,the mixtures presented with color change.CONCLUSION： Omeprazole sodium is compatible with 0.9% NS,5% GS or 10% GS,preferably with 0.9% NS.The mixtures of omeprazole sodium with 5% GS or 10% GS are preferably stored at a temperature of below 25 ℃ and used within 2 hrs.Omeprazole sodium is contraindicated to use with fructose,10% calcium gluconate solution or 25% magnesium sulfate.
出处
《中国医院用药评价与分析》
2011年第12期1103-1105,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
奥美拉唑钠
溶剂
配伍稳定性
时间
温度
PH值
Omeprazole sodium
Solvent
Compatibility stability
Time
Temperature
pH value
