摘要
目的研究甘草黄酮(LF)对T2DM大鼠血糖、血脂等生化指标的影响。方法将实验大鼠分为模型组(DM)、高剂量给药组(HLF)、低剂量给药组(LLF)、正常对照组(Con)和正常给药组(CLF)。分别以LF或溶剂灌胃,5周后检测实验大鼠的空腹血糖、血脂等生化指标及肝体比、肾体比和脂体比。结果高剂量LF(300mg.kg-1.d-1)显著降低了糖尿病大鼠的FBG、TG、TC、LDL-C、FFA、TNF-α、瘦素、肝体比和肾体比,并显著提高了糖尿病大鼠的T-AOC、ISI和脂体比。结论 LF具有降低糖尿病大鼠血糖、调节脂代谢紊乱的作用,并可显著改善胰岛素抵抗。
Objective To study the effect of licorice flavonoids（LF） on fasting blood levels of glucose（FBG）,lipids,insulin,adipokines and other biochemical indicators. Methods The type 2 diabetic rat model was replicated by feeding high-fat and high-sugar diet combined with low-dose streptozotocin（STZ） injection.The diabetic rats were divided into model group（DM）,high-dose LF treatment group（HLF） and low-dose LF treatment group（LLF）.Other 20 normal rats were divided into control group（Con） and control treatment group（CLF）.Rats in different groups were administered LF（100mg or 300mg·kg^-1·d^-1） or solvent（propylene glycol） respectively.Five weeks later,the levels of fasting levels of glucose（FBG）,triglycerides（TG）,total cholesterol（TC）,free fatty acids（FFA）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,total antioxidation capability（T-AOC）,insulin（Ins）,tumor necrosis factor alpha（TNF-α） and leptin were examined.Insulin sensitivity index（ISI）,liver index,kidney index and the relative weight of abdominal adipose tissue were calculated. Results The high-dose LF（300mg·kg-1·d-1） treatment significantly decreased the levels of FBG,TG,TC,LDL-C,FFA,T-AOC,TNF-α,leptin,liver index and kidney index,and increased the levels of T-AOC,ISI and the relative weight of abdominal adipose tissue.Compared with high-dose treatment,low dose of LF was less effective. Conclusion LF significantly decreases the blood glucose level,improves the lipid metabolic disorders and ameliorates insulin resistance in type 2 diabetic rats.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2012年第1期65-69,共5页
Chinese Journal of Diabetes
基金
教育部留学回国人员科研启动基金资助项目(2005年)
关键词
甘草黄酮
糖尿病
2型
胰岛素抵抗
血糖
血脂
Licorice flavonoids
Diabetes mellitus
type 2
Insulin resistance
Blood glucose
Blood lipid
