摘要
目的探讨血清免疫球蛋白A（IgA）水平在手足口病诊断中的临床意义。方法检测65例手足口病患儿血清IgA水平，同时选择65例健康查体儿童作为健康对照组。根据手足12I病患儿血清IgA水平分为血清IgA阳性组和IgA阴性组，比较两组患儿热程及病程。结果手足El病组患儿血清IgA水平（μg／L）明显低于健康对照组，血清IgA阳性率明显高于健康对照组（1gA：0．70±0．46比1．91±0．96，IgA阳性率：69．23％比7．69％，P〈0．01和P〈0．05）。血清IgA阳性组患儿的热程（d）、病程（d）均长于血清IgA阴性组（热程：4．35±0．89比2．85±0．58，病程：7．22±0．86比5．06±0．95，均P〈0．05）。结论手足口病患儿血清IgA降低，提示病毒感染期间免疫功能下降，影响手足口病的热程与病程，对临床有指导意义。
Objective To evaluate the clinical significance of serum level of immunoglobulin A （IgA） in children with hand-foot-mouth disease （HFMD）. Methods The levels of serum IgA were determined in 65 children with HFMD. Samples from 65 normal healthy children at the same period were taken as the control group. Sixty-five children with HFMD were divided into positive group and negative group, based on different levels of serum IgA. The thermal process and course of disease were compared between the two groups. Results The levels （μg/L） of serum IgA in HFMD group was significantly lower than that in healthy control group, and positive rate of serum IgA of HFMD group was significantly higher than that in the healthy control group （IgA： 0.70±0.46 vs. 1.91±0.96, IgA positive rate： 69.23% vs. 7.69%, P〈0.01 and P〈0.05）. The thermal process （days） and disease course （days） of serum IgA positive group were longer than those of serum IgA negative group （thermal process： 4.35±0.89 vs. 2.85±0.58, disease course： 7.22±0.86 vs. 5.06±0.95, both P〈0.05）. Conclusion The decrease of serum IgA of children with HFMD suggests the declination of immune function during the viral infection, which may affect the thermal process and course of disease and make a good clinical guidance.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2012年第1期42-43,共2页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
手足口病
血清免疫球蛋白A
肠道病毒
Hand-foot-mouth disease
Serum immunoglobulin A
Enterovirus
