摘要
目的观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)及5-氟尿嘧啶(5-Fu)(FOLFOX方案)对局部进展期或转移性胃癌的疗效及毒副反应。方法奥沙利铂(L-OHP)85mg/m2静滴2h第1天,亚叶酸钙(CF)200mg/m2静滴2h第1天,5-Fu400mg/m2静推紧随亚叶酸钙后第1天,5-Fu1500mg/m2微泵持续静滴46h。每2周为1个周期,连用4个周期评价疗效。结果 CR1例(4.3%),PR8例(34.8%),SD10例(43.5%),PD4例(17.4%),总有效率为39.1%。中位TTP为5.4个月,中位生存期为10.6个月。Ⅲ、Ⅳ度不良反应为白细胞减少3例(13.0%),贫血1例(4.3%),恶心呕吐1例(4.3%),感觉神经毒性2例(8.7%)。结论 FOLFOX方案治疗晚期胃癌疗效肯定,副反应较轻,患者耐受性好。
Objective To study the clinical efficacy of FOLFOX regimen, oxaliplatin （L-OIl：P） combined with fluorouracil （5-Fu） and calcium folinate （CF）, in the treatment of locally advanced or metastatic gastric cancer. Methods All the patients were treated with L-OHP 85 mg/m^2 i.v. 2 h and CF 200 mg/m^2 i.v. 2 h, followed by 5-Fu 400 mg/m^2 i.v. on day 1, and then 5-Fu 1 500 mg/m^2 c.i.v. 46 h, every 2 weeks, for four cycles. Results Of the 23 pa- tients, one case （4.3%） reached complete remission （CR）, 8 cases （34.8%） reached partial remission （PR）, 10 cases （43.5%） reached stable disease （SD）, and 4 cases （17.4%） reached progressive disease （PD）. The overall response rate was 39.1%. The median TTP and median survival time was 5.4 months and 10.6 months, respectively. The grade 3 and 4 adverse reactions included leukopenia in 3 cases （13.0%）, anaemia in 1 case （4.3%）, nausea and vomiting in 1 case （4.3%）, and neurotoxicity in 2 cases （8.7%）. ConcIusion The FOLFOX regimen is effective for treating locally advanced or metastatic gastric cancer, with no severe adverse reactions and good patient tolerance.
出处
《海南医学》
CAS
2012年第1期46-48,共3页
Hainan Medical Journal
