摘要
目的评价飞秒激光LASIK（FS—LASIK）制作的角膜瓣的预测性、可重复性和均匀性，并与前弹力层下准分子激光角膜磨镶术（SBK）进行比较，从而了解FS—LASIK的制瓣特点。方法临床系列病例对照研究。收集2010年6月至8月在天津市眼科医院行角膜屈光手术的患者66例，其中FS—LASIK组32例63只眼，对照组SBK组35例69只眼（其中1例1只眼行FS—LASIK，另1只眼行SBK）。应用Visante OCT在术后1d采集水平和垂直子午线上距离角膜顶点1mm，2mm，3mm以及角膜顶点共13个点的角膜瓣厚度。统计方法为方差分析或t检验，以P〈0．05表示有统计学意义。结果FS—LASIK组的平均中央角膜瓣厚度为（97．49±7．34）μm，SBK组的平均中央角膜瓣厚度为（112．93±9．99）μm。FS—LASIK组实际中央角膜瓣厚度与平均中央角膜瓣厚度差值绝对值的均数为（5．74±3．98）μm，SBK组为（8．11±5．75）μm，两者相比差异有统计学意义（t=2．83，P=0．005）。角膜瓣的空间形态：FS—LASIK组在距离角膜顶点不同距离的位置，瓣厚度基本均匀一致（F=1．206，P=0．303）；SBK组呈中央薄周边厚的形态，进刀部位角膜瓣厚度高于出刀部位，两者比较差异有统计学意义（t=7．246，P=O．009）。结论飞秒激光制瓣与机械刀相比，在预测性和可重复方面更有优势，从中央到周边角膜瓣厚度均匀一致。
Objective To evaluate and compare the accuracy, reproduclblhty and regularity ot corneal flap created with femtosecond laser （FS-LASIK） and Sub-Bowman＇s Keratomileusis （SBK） refractive surgery. Methods In this study, 66 cases which underwent corneal refractive surgery were included. Sixty-three eyes of 32 cases were treated with FS-LASIK. Sixty-nine eyes of 35 cases were treated with SBK. Visante OCT was used to measure the corneal flap thickness 1 day postoperatively. The thickness of thirteen measuring points across each flap, which were lmm, 2mm, 3mm away from vertex of cornea on the horizontal and vertical respectively and the vertex of cornea itself, was evaluated. The results were analyzed with t-test or ANOVA by SPSS17.0 software. Resuits The average thickness of flap on the vertex of cornea in femtosecond group was （97.49±7.34）μ m; for the SBK group, this value was （112.93±9.99） μm. The average of absolute difference between actual and average thickness was （5.74±3.98） μm and （8.11±5.75） μm in the FS-LASIK and SBK group respectively, with statistical significant difference between these two groups （t =2.83, P = 0.005）. Flap morphology： The flap thickness showed good uniformity for different location away from the vertex in FS-LASIK group （F =1.206, P =0.303）, while flap thickness in the central area was thinner than peripheral area for the SBK group. The mean flap thickness of knife in-side was significant higher than the knife out-side （t =7.246, P =0.009）. Conclusions Compared to SBK, the cornea flap of FS-LASIK shows more advantage in the accuracy and reproducibility, and the cornea flap is more regular from central to peripheral area.
出处
《中国实用眼科杂志》
CSCD
北大核心
2012年第1期65-68,共4页
Chinese Journal of Practical Ophthalmology
基金
基金项目：天津市自然科学基金（07JCYBJC09500）天津市卫生局攻关项目（10KG109）
