摘要
目的研究COPD患者血清中白三烯B4(LTB4)和肿瘤坏死因子(TNF-α)浓度的改变及其临床意义。方法收集COPD患者急性发作期(30例)和缓解期(30例)以及正常对照组(30例)的血清,检测血清中LTB4和TNF-α。结果①30例COPD患者急性发作期LTB4为14.9±6.3μg/L,30例缓解期为5.7±4.1μg/L,30例正常对照组为1.5±0.7μg/L,三组差异有显著性,P<0.05;②COPD患者急性发作期TNF-α为1154.5±107.6 ng/L,缓解期为776.3±82.5 ng/L,正常对照组为440.0±78.7 ng/L,三组差异有显著性,P<0.05。结论 COPD的急性发作期,LTB4和TNF-α水平的升高反映了氧化应激增强。
Objective To Study the changes and clinical significances of leukotrieneB4 and tumor necrosis factor-α in serum in patients of chronic obstructive pulmonary disease （COPD）. Methods serum of 30 cases in acute episode COPD （AECOPD） , 30 cases of period of remission, and 30 normal person were collected. The concentrations of leukotrieneB4 and tumor necrosis factor-α in serum were detected. Results ① The concentration of LTB4 in serum in AECOPD was 14. 9±6. 3μg/L,5.7 ＋4. 1 μg/L in remission of COPD and 1.5 ＋ 0. 7 p^g/L in normal controls, and there were significant differences between the groups（ P 〈 0. 05 ）.② The concentration of TNF-α in serum in AECOPD was 1154.5 -＋ 107.6 ng/L,776. 3±82.5 ng/L in remission of COPD and 440. 0±78.7 ng/L in normal controls, and there were significant differences between the groups （ P 〈 0. 05 ）. Conclusion The concentration of LTB4 and TNF-α in serum in AECOPD patients were raised when oxidation stress was reinforced.
出处
《临床肺科杂志》
2012年第3期459-460,共2页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺病
白三烯B4
肿瘤坏死因子
chronic obstructive pulmonary disease
leukotrieneB4
tumor necrosis factor-α
