摘要
目的研究糖化血红蛋白（HbAlc）对非糖尿病代谢综合征（MS）诊断的敏感性和特异性以及HbAlc与心血管危险因素的相关性。以期获得一种简单、实用的代谢综合征诊断方法。方法分析6292名健康体检者（中位年龄45岁，排除糖尿病患者）HbAlC指标分布以及其与心血管危险因素的关系。分析HbAlc预测MS的能力。所有体检者进行人体测量和空腹血糖、血脂和HbAlc测定。MS定义采用中华医学会糖尿病分会2004年制定的诊断标准。结果MS的检出率是11．24％。HbAlc随年龄和体质指数增加而上升。受检者按HbAlc四分位数分组后，随着HbAlc增加心血管危险因素明显增高。HbAlc检测值为5．8％时，可预测MS存在。按性别分组时，女性与男性预测MS的截点值相同，曲线下面积0．79。结论代谢综合征的非糖代谢组分如果已经达到MS标准，则应查HbAlc，如大于5．8％，说明糖代谢也一定程度上受损，应该高度重视，防止其进一步恶化。
Objective To examine the sensitivity and specificity of glycated haemoglobin Alc （HbAlc） in predicting metabolic syndrome （MS） and its association with cardiovascular risk factors. Methods In 6292 adults （ median age 45 years） who participated in a medical check-up program, analysis of distribution of HbAle and its association with various cardiovascular risk factors was performed. The ability of HbAlc to predict MS was evaluated. Anthropometric measurements were made and fasting plasma glucose, lipid profiles and HbAlc were tested. Results The prevalence of MS was 11.24%. Cardiovascular risk factors were significantly increased as the serum level of HbAlc increased. HbAlc of 5.8% predicted the presence of MS. Females showed the same cut-off of HbAlc for the prediction of MS with males （the area under the curve of the females was higher than that of the males ）. Conclusion HbAlc was increased as cardiovascular risk factors increased and HbA1 c of 5.8% may predict the presence of MS. HbAlc might be a predictive measure of MS and cardiovascular diseases in adults.
出处
《中华健康管理学杂志》
CAS
2012年第1期25-27,共3页
Chinese Journal of Health Management
基金
国家自然科学基金（30971395）
关键词
代谢综合征X
血红蛋白A
糖基化
血糖
Metabolic syndrome X
Hameglobin A, glycosylated
Blood glucose
