摘要
目的 :探讨术中动脉内化疗的临床应用。方法 :对实验组 11例口腔癌 (9例舌癌 ,2例口底癌 )患者行联合根治术及皮瓣修复术 ,氮芥术中舌动脉内给药 (浓度为 1mg/ml,剂量为 5mg) ,对照组 16例口腔癌 (13例舌癌 ,3例口底癌 )患者仅行手术 ,并同期行皮瓣修复。术后观察患者全身和局部反应并作近期随访。结果 :实验组无明显全身及局部反应 ,11例皮瓣全部存活 ,近期随访 (3～ 12月 ) ,实验组局部复发率为 9 1% (1/ 11) ,对照组为 18 8% (3/ 16 )。结论 :术中一次性动脉内化疗不影响皮瓣存活 ,临床不良反应小 ,可望减少局部复发 ,是一种治疗口腔鳞癌的有效辅助手段。
Objective: To discuss the general and local side effects and clinic appliance of the intra arterial chemotherapy, and evaluate the short time clinic effects of the intra arterial chemotherapy. Methods: From February, 1997 to December, 1997 11 patients with oral cancer (9 cases with lingual carcinoma, 2 cases with mouth carcinoma) were received one shot chemotherapy during operation by NH\-2 catheterizing of lingual arteries (concentration of 1 mg/ml, dosage of 5 mg), and the other 16 oral cancer patients (13 cases with lingual carcinoma, 3 cases with mouth carcinoma) were only received operation as the control. At the same time, all patients were treated with Chinese flaps or Major pectoris myocutanous flaps homochronously. Then the general and local side effects including the flap complexion were observed 1 week post operatively and the follow up was done in a shot time of 3～12 months. Results: No obvious general and local side effects (including blood, mal function of liver and kidney, flap complexion, vomit and hemiplegia) happened and all the 11 flaps (6 Chinese flaps, 5 major pectoris myocutanous flaps) were alive in the experimental group. The local recurrent rate of the experimental group was 9.1%, while the rate was 18.8% in the control group (following up of 3～12 months). There was no significant difference between the experiment and the control groups by Student t test. Conclusion: The one shot chemotherapy intra operationally is a method with few side effects, and it doesn't injure the homochronously reconstructed flaps. It might be an effective means of reducing the local recurrence of oral cancer.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2000年第1期34-36,共3页
West China Journal of Stomatology
基金
国家自然科学基金!(编号 3 9670 786)
关键词
氮芥
口腔鳞癌
皮瓣修复
伤口愈合
NH\-2\ \ intra arterial chemotherapy\ \ oral carcinoma\ \ flap reconstruction
