摘要
目的观察健脾扶正汤择时用药联合FOLFOX方案时辰化疗治疗晚期胃癌对生活质量及免疫功能的影响。方法 80例患者随机分成两组,两组均采用FOLFOX方案时辰化疗,21 d为1个周期;2个周期评价疗效。治疗组加用健脾扶正汤择时用药治疗,对照组加用健脾扶正汤非择时用药治疗。14 d为1个疗程,2个疗程评价疗效。观察临床证候变化、生活质量、免疫功能及毒副反应变化。结果两组生活质量情况比较,食量增加:治疗组与对照组分别为75.0%和55.0%;睡眠改善:治疗组与对照组分别为80.0%和57.0%(P<0.05)。免疫功能变化比较,治疗组治疗后CD3+、CD4+/CD8+比值明显高于治疗前(P<0.01),而对照组治疗后CD3+、CD4+/CD8+比值明显低于治疗前(P<0.05)。结论健脾扶正汤择时用药联合FOLFOX方案时辰化疗治疗晚期胃癌可提高机体免疫功能及生活质量,延长生存期。
Objective To observe the impacts on the life quality and immune function for the patients with gastric cancer at the later stage in the treatment with timing medication of jianpi fuzheng decoction allied with chemotherapy at time division of FOLFOX program.Methods 80 cases were divided randomly into two groups.The chemotherapy at time division of FOLFOX program was adopted in either group,in which 21 days made 1 circle.The efficacy was assessed in 2 circles.In treatment group,the timing medication of jianpi fuzheng decoction was supplemented.In control group,the non-timing medication of jianpi fuzheng decoction was applied.14 days made 1 session.The efficacy was assessed in 2 sessions.The changes in clinical symptoms,life quality,immune function and toxic side reaction were observed.Results In the comparison of the life quality between two groups,the food intake was increased by 75.0% in treatment group and by 55.0% in control group;the sleep was improved by 80.0% in treatment group and by 57.0% in control group（P0.05）.In comparison of the immune function,after treatment,the ratio of CD3＋,CD4＋/CD8＋ in treatment group was higher remarkably than that before treatment（P0.01）;that in control group was lower remarkably as compared with that before treatment（P0.05）.Conclusion The treatment with timing medication of jianpi fuzheng decoction allied with chemotherapy at time division of FOLFOX program improves the organic immune function and life quality and prolongs the life span for the patients with gastric cancer at the later stage.
出处
《世界中西医结合杂志》
2012年第2期134-136,162,共4页
World Journal of Integrated Traditional and Western Medicine
基金
广西壮族自治区中医药管理局自筹经费科研课题(No.gzzc0974)
关键词
晚期胃癌
健脾扶正汤
择时用药
时辰化疗
生活质量
免疫功能
Gastric Cancer at the Later Stage Jianpi Fuzheng Decoction Timing Medication Chemotherapy at Time Division Life Quality Immune Function
