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Wnt诱导分泌蛋白-1与疾病

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摘要 Hashimoto等在对大鼠突变后黑色素细胞进行RNA差异筛选时第一次发现了有一种新的基因表达，此种基因后来称为WISP1（Wnt诱导分泌蛋白-1）。随后的研究发现WISP1广泛表达在人类的多种组织器官中，但含量有所差异。研究中发现WISP1同时在调控细胞的分化、突变、凋亡及机体的应激和免疫等过程中起着重要的作用，具有促进细胞粘附、促进细胞增殖以及刺激细胞发生转移等的生物学功能，
作者 田雨 蒋幼凡
机构地区 四川省安岳县人民医院呼吸内科 重庆医科大学附属第二医院呼吸内科
出处 《中国实用医刊》 2012年第5期88-89,共2页 Chinese Journal of Practical Medicine
关键词 分泌蛋白 蛋白-1 WNT HASHIMOTO 黑色素细胞 疾病 基因表达 生物学功能
分类号 R363 [医药卫生—病理学]
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参考文献17

  • 1Hashimoto Y,Shindo-okada N,Tani M. Identification of genes differentially expressed in association with metastatic potential of K1735 murine melanoma by messenger RNA differential display[J].Cancer Research,1996,(22):5266-5271.
  • 2Brigstock DR. The CCN family:a new stimulus package[J].Journal of Endocrinology,2003,(02):169-175.
  • 3唐琼兰,刘卫平,张文燕,杨帆,何妙侠,夏庆杰,李甘地.CYR61和血管内皮生长因子在结外鼻型NK/T细胞淋巴瘤中的表达及其意义[J].中华血液学杂志,2006,27(10):661-665. 被引量：24
  • 4Su F,Ovcrhohzer M,Besser D. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase[J].Genes and Development,2002,(01):46-57.doi:10.1101/gad.942902.
  • 5马焕芝,曾炳芳.CCN家族与骨的形成与修复[J].国际骨科学杂志,2007,28(2):71-73. 被引量：3
  • 6田超,周总光.结肠癌发病机制研究的新位点-WISP-1[J].华西医学,2007,22(1):181-182. 被引量：9
  • 7Harlow CR,Hillier SG. Connective tissue growth factor in the ovarian paracrine system[J].Molecular and Cellular Endocrinology,2002,(1-2):23-27.doi:10.1016/S0303-7207(01)00702-X.
  • 8Penllica D,Swanson TA,Welsh JW. WISP genes are members of the cornective tissue growth factor family that are up-regulated in Wnt-1 transfomed cells and aberrantly expressed in human colon tumors[J].Proceedings of the National Academy of Sciences(USA),1998,(25):14717-14722.
  • 9Colston JT,Rosa SD,Koeheler M. Wnt-induced serected protein-I is a prohypertrophic and profibrotic growth factor[J].American Journal of Physiology-Heart and Circulatory Physiology,2007,(03):H1839-H1846.doi:10.1152/ajpheart.00428.2007.
  • 10Xie D,Nakachi K,Wang H. Elevated levels of connective tissue growth factor,WISP-1,and CYR61 in primary breast cancers associated with more advanced features[J].Cancer Research,2001,(24):8917-8923.

二级参考文献52

  • 1Zhi-JunZeng Lian-YueYang XiangDing WeiWang.Expressions of cysteine-rich61,connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance[J].World Journal of Gastroenterology,2004,10(23):3414-3418. 被引量：28
  • 2Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3 - only member of the Bcl - 2 family and candidate mediator of p53 - induced apoptosis[ J ]. Science,2000, (288): 1 053 ～ 1 058.
  • 3Nakano K, Vousden K H. PUMA, a novel proapoptotic gene, is induced by p53[ J ]. Mol Cell ,2001, (7): 683 ～ 694.
  • 4Yu J,Zhang L, Hwang P M,et al. PUMA induces the rapid apoptosis of colorectal cancer Cells[J] .Mol Cell,2001,(7):673～ 682.
  • 5Lin M T, Chang C C, Chen S T, et al. Cyr61 Rxpression Confers Resistance to Apoptosis in Breast Cancer MCF - 7 Cells by a Mechanism of NF - { kappa}B - dependent XIAP Up - Regulation[J] .J Biol Chem,2004, (279) :24 015 ～ 24 023.
  • 6Hishikawa K,Oemar B S,Tanner F C,et al.Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF- 7[ J ].J Biol Chem, 1999, (274) :37 461 ～ 37 466.
  • 7Hu S, Snipas S J, Vincenz C, et al. Caspase - 14 is a novel developmentally regulated protease[ J]. J Biol Chem, 1998, (273) :29 648 ～ 29 653.
  • 8Soon L L, Yie T A, Shvarts A, et al. Overexpression of WISP - 1 downregulated motility and invasion of lung cancer cells through inhibition of Rac activation[J].J Biol Chem,2003, (278): 11 465～ 11 470.
  • 9Shimo T,Kubota S,Kondo S,et al.Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line [J]. Cancer Lett, 2001, (174) :57 ～ 64.
  • 10Babic A M, Kireeva M L, Kolesnikova T V, et al. CYR61, a product of a growth factor- inducible immediate early gene, promotes angiogenesis and tumor growth[ J] .Proc Natl Acad Sci, 1998, (95):6 355 ～ 6 360.

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中国实用医刊
2012年 第5期

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