摘要
目的探讨甲胎蛋白异质体(AFP-L3)在原发性肝癌(PLC)早期诊断的意义。方法分别用微量离心柱法和电化学发光法检测170例治疗前PLC患者和130例慢性肝病患者血清中的AFP-L3和AFP。结果 PLC组的AFP-L3敏感性和中位水平分别为84.12%和16.85,高于良性肝病组(P<0.05)。20<AFP<200ng/ml时AFP-L3的敏感性为74.36%,特异性为74.65%。AFP-L3水平及阳性率随肝癌分期和肿瘤增大升高,Ⅰ期肝癌和小肝癌的敏感性分别为60.87%和66.67%。结论 AFP-L3在PLC早期诊断中具有重要临床价值。
Objective To explore the clinical significance of Lens culinaris-reactive a-Fetoprotein（AFP-L3） detection in early diagnosis of primary liver cancer（PLC）.Methods AFP-L3 was isolated by using microspincolumn coupled with lens culinaris agglutinin（LCA）in 130 patients with chronic liver disease and 170 patients with PLC.AFP and AFP-L3 were detected with electrol chemiluminescent immunoassay and microspincolumn method,the proportion of AFP-L3 levels were calculated.Results There were significant differences in the sensitivity and median level of AFP-L3（84.09%,16.85）between the patients of PLC and CLD.The sensitivity and specificity of AFP-L3 were 74.36% and 74.65% according to 20AFP200 ng/mL.The sensitivity and level of AFP-L3 were rised as the increase of tumor stages and tumor size.The sensitivity of stageⅠand small PLC（3 cm） were 60.87% and 66.67%.Conclusion There are significant clinical values in the early diagnosis of PLC with the detection of AFP-L3.
出处
《福建医药杂志》
CAS
2012年第1期3-6,共4页
Fujian Medical Journal
基金
福建省医学创新课题(2007-CXB-5)
关键词
甲胎蛋白
甲胎蛋白异质体
原发性肝癌
早期诊断
Alpha-fetopmteins
Lens culinaris-reactive a-Fetoprotein
primary liver cancer
early diagnosis
