摘要
目的:观察不同间隔时间预防用维生素E(VE)对消炎痛诱发胃黏膜损伤的保护作用。方法:取100只小鼠,随机均分为给药不同间隔时间(0、15、30、45、60min)的模型组和VE组,共10组。模型组的小鼠给予生理盐水灌胃,VE组的小鼠给予VE灌胃;然后各组小鼠再分别按相应的间隔时间给予消炎痛灌胃;4h后测定胃黏膜损伤指数。结果:给VE不同间隔时间组的胃黏膜损伤指数均明显低于相对应间隔时间的模型组(P<0.01);给VE间隔30min组的胃黏膜损伤指数明显低于其余VE间隔时间组(P<0.01)。结论:VE能明显降低消炎痛诱发胃黏膜损伤;用VE间隔30min再用消炎痛,VE对预防消炎痛诱发胃黏膜损伤的效果最佳。
Objective：Observation vitamin E （VE） different interval use by gastric mncosal injury in prevention indomethacin induced. Methods：Take 100 only miees,random are divided into drug different intervals （0,15,30,45,60 min） of model groups and VE groups, 10 groups. Model groups mices of given saline intragastric, VE groups mices by given VE intragastric;then each group mices respectively in corre- sponding intervals given indomethacin intragastric, Determination of mites gastric mucosal injury index in 4 hours. Results：Gastric mucosal injury indexs of VE different interval groups were significantly lower than the corresponds interval timing model groups （P 〈 0.01 ） ;gastric mucosal in- jury indexs of VE interval 30min group significantly lower than the rest of VE interval groups （ P 〈 0.01 ）. Conclusion ： VE can significantly reduce indomethaein - induced gastric mucosal injury ; VE with indomethacin by 30min interval, VE on indomethacin - induced gastric mucosal injury prevention works best.
出处
《中外医学研究》
2012年第7期141-142,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
维生素E
预防
间隔时间
消炎痛
胃黏膜损伤
Vitamin E
Prevention
Interval
Indomethacin
Gastric mucosal injury
