摘要
少突胶质前体细胞形成中枢神经系统轴突的髓鞘。近年来,少突胶质前体细胞(OPC)以具有自我更新、分化及髓鞘化中枢神经系统轴突的潜能而引起关注。本文将综述在发育过程中调控OPC分化的分子机制,主要包括细胞骨架水平、转录水平、时空水平以及轴突水平等方面。
In the CNS, oligodendrocytes are responsible for the formation of myelin that surrounds axons. In recent years, oligodendrocyte precursor cells （OPCs） have gained much attention for their potential of self-renew, differentiation, and remyelination of the CNS. The molecular mechanisms controlling OPCs differentiation during development, including oligodendroglial cytoskeleton, transcription, spatiotemporal regulation and axonal inhibition were reviewed.
出处
《组织工程与重建外科杂志》
2012年第1期56-59,共4页
Journal of Tissue Engineering and Reconstructive Surgery
基金
第48批中国博士后科学基金面上资助项目(20100481475)
关键词
少突胶质前体细胞
分化
调节
髓鞘
Oligodendrocyte precursor cells
Differentiation
Regulation
Myelin
