摘要
目的:制备5-氟尿嘧啶/纳米蒙脱土缓释系统,并对其进行体外释药研究.方法:采用离子交换法将5-氟尿嘧啶插层到蒙脱土片层间,通过X射线衍射(X ray diffraction,XRD)和FTIR对5-氟尿嘧啶/纳米蒙脱土缓释系统的性能进行表征,紫外分光光度计定量分析药物的体外累积释药量.结果:插层后的蒙脱土层间距由1.492 nm增大到1.736 nm,说明5-氟尿嘧啶已经成功插入蒙脱土片层间;药物体外持续释放时间超过6 h,证实制备的复合药物具有良好的缓释效果.结论:5-氟尿嘧啶/纳米蒙脱土缓释系统具有良好的缓释效果.
AIM： To prepare sustained-release 5-fluoroura- cil/nano montmorillonite and and to evaluate its in vitro release characteristics. METHODS： 5-fluorouracil was intercalated into the interlayer of montmorillonite by ion- exchange, The in vitro release characteristics of 5-fluorouracil/nano rnontmorillonite were ana- lyzed by XRD and FTIR. RESULTS： The spacing of 5-fluorouracil/nanomontmorillonite increased from 1.492 nm to 1.736 nm, showing that 5-Fu had been intercalated into the interlayer of Ca-MMT. Sustained release of 5-fluorouracil in vitro exceeded 6 h, proving that the composite has a good slow-release property. CONCLUSION： 5-fluorouracil/nano montmorillonite possesses a wonderful sustained-release property.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第5期414-417,共4页
World Chinese Journal of Digestology
基金
广东省自然科学基金资助项目
No.7300452~~
关键词
5-氟尿嘧啶
纳米蒙脱土
缓释
5-fluorouracil
Nano montmorillonite
Sustained-release
